PhD position - Deciphering the mechanisms of pathological IgG aggregation in oncohematological diseases

12 Feb 2024
Job Information

Organisation/Company

University PJ Safarik Kosice

Research Field

Physics » Biophysics
Chemistry » Biochemistry

Researcher Profile

First Stage Researcher (R1)

Country

Slovakia

Application Deadline

15 Apr 2024 - 00:00 (Europe/Bratislava)

Type of Contract

Temporary

Job Status

Full-time

Hours Per Week

37,5

Offer Starting Date

1 Sep 2024

Is the job funded through the EU Research Framework Programme?

Not funded by an EU programme

Is the Job related to staff position within a Research Infrastructure?

No

Offer Description

This PhD project offers a unique opportunity to delve into the molecular intricacies of oncohematological diseases like multiple myeloma and light chain amyloidosis. These conditions, marked by the aggregation of pathological immunoglobulin G (IgG) light chains, lead to severe health complications and are currently classified as incurable. You will employ a range of structural and biophysical techniques to study these processes ex vivo, gaining insights into the complex mechanisms at play in these diseases. Your work will contribute to a deeper understanding of the aggregation mechanisms of pathological IgGs, potentially leading to new therapeutic strategies for these challenging conditions. As a PhD candidate, you will be actively involved in experimental design, data collection, and analysis. You will also examine the role of chaperone domains as potential binders and therapeutic agents. This project presents a significant opportunity to contribute to a field of high medical importance.

Project goals:

1) Investigate the biological and biochemical factors contributing to the aggregation of pathological IgG light chains.

2) Explore the interactions between serum proteins, lipid vesicles, and cell surface properties that catalyze or drive this aggregation process.

3) Examine the application of chaperone domains as potential disaggregation drugs.

Requirements

Research Field

Physics » Biophysics

Education Level

Master Degree or equivalent

Languages

ENGLISH

Level

Excellent

Additional Information
Work Location(s)

Number of offers available

2

Company/Institute

University PJ Safarik Kosice

Country

Slovakia

Geofield

Where to apply

E-mail

[email protected]

Contact

State/Province

Slovakia

City

Kosice

Website

https://www.upjs.sk/

Street

Trieda SNP 1, Kosice, Slovakia

Postal Code

04001

E-Mail

[email protected]

Phone

+421948729180

STATUS: EXPIRED