iMM is looking for a motivated post-doc to join the Gomes Lab at iMM-Lisbon, funded by a European Research Council (ERC) Synergy Grant. The position represents an exciting opportunity to work as part of a collaborative ERC synergy grant with Michael Way (the Francis Crick Institute, London) and Carolyn Moores (Birkbeck, London) to investigate the molecular, cellular and physiological diversity of the Arp2/3 complex.
The Arp2/3 complex consisting of seven protein subunits is essential to stimulate dynamic branched actin networks during multiple fundamental cellular processes. The Way lab previously demonstrated that Arp2/3 subunit composition dramatically affects the formation and stability of branched actin networks (Abella et al., 2016). Moreover, the Gomes lab demonstrated that specific Arp2/3 isoforms are essential for normal muscle development, specifically the position of the nucleus in the periphery of the myofibers and the formation of muscle triads (Roman et al. 2017).
The proposed project, which involves a close and interactive collaboration with the labs of Carolyn Moores (Birkbeck, London) and Michael Way (Crick, London), will use structural, biochemical and cellular approaches to understand the regulation and properties of the eight different human Arp2/3 complexes during muscle development and regeneration. The successful candidate(s) will be expected to drive their own independent research programme using high resolution microscopy in combination with biochemistry, optogenetics and molecular biology approaches.
Abella et al., Nature Cell Biol 2016
Roman et al., Nature Cell Biol 2017
Roman et al., Science 2021
For more information on the Gomes laboratory, please visit our website here .
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