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into the COF structure. The D and A units will be electronically distinct but structurally analogous in terms of linker length and geometric alignment, enabling their mutual exchangeability and systematic tuning
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The International Institute of Molecular Mechanisms and Machines Polish Academy of Sciences | Poland | about 2 months ago
, protein biochemistry, quantitative proteomics, and functional genomics to investigate transcriptional regulation across multiple spatial and molecular scales. The project encompasses three interconnected
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, in the transition between the two catalytic conformations of the spliceosome. Our current model predicts that direct interaction between the Prp8-RT beta-hairpin loop and the U2 sequence between helix
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Description of programme/project/undertaking Recent developments in biotechnology, including the enormous progress in sequencing technologies and public accessibility to many bioinformatic data, create new
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International Centre for Translational Eye Research / Institute of Physical Chemistry, Polish Academy of Sciences | Poland | 5 days ago
genetic engineering. Candidates should be familiar with single-cell and/or spatial RNA-sequencing and mice models to develop multi-omics method for profiling of intraocular tumours. The successful candidate
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, regulation of gene expression using recombinant AAV viruses, proteomics, RNA sequencing, complex biochemistry, neurotransmitter analysis, confocal microscopy, and cell culture. By joining the project, you will
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The International Institute of Molecular Mechanisms and Machines Polish Academy of Sciences | Poland | 28 days ago
they play crucial roles in human diseases such as Parkinson’s disease, Alzheimer’s disease, and cancer. As new means to combat these diseases, we leverage sequence-specific proteases to reduce the
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Recruitment for the position of Assistant Professor in the Laboratory of Genomics and bioinformatics
Hirszfeld Institute of Immunology and Experimental Therapy Polish Academy of Sciences | Poland | about 2 months agoidentification of genetic variants and integration of molecular, biological and clinical data. 3. Consulting on research projects concerning experimental design, selection of sequencing methods, and assessment
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in multiple compartments of the cell. In this project, we will establish a global solution to predict the organellar localization of unknown proteins. To this end, we will conduct a comprehensive
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/destabilization of several postulated intermediate structures of the catalytic triplex on splicing catalysis. The RNA core of the spliceosome undergoes multiple changes during the catalytic phase of splicing