Label-free and rapid optical imaging, detection and sorting of leukemia cells
Project is carried out within the TEAM-NET programme of the Foundation for Polish Science
Leukemias are malignancies originating from hematopoietic or lymphoid precursors caused by genetic lesions leading to biochemical, proteomic and metabolomics abnormalities. Current leukemia diagnostics is based on genetic and phenotypic characterization of cancer cells. The project aims to develop the first Stimulated Raman Scattering (SRS) microscopic-microfluidic system for non-invasive imaging of live cells and apply it to rapid leukemia cell imaging, diagnostics and sorting. Multidisciplinary partners establishing the consortium will characterize Raman spectra of leukemic cells and link them to biological features of the disease. These data will be thereafter used to design and construct, microfluidic diagnostic device utilizing SRS microscopy which should provide cost-effective early diagnostics and follow up of leukemia patients.
Key responsibilities include:
Supervision of molecular profiling of leukemic cells at a genome and transcriptome level. Analysis of genome-wide transcriptome data from single cells.
Independent research, supervision, planning, day-to-day lab management, collaborations and outreach.
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