8 Feb 2024
Job Information
- Organisation/Company
Institute of Bioorganic Chemistry Polish Academy of Sciences- Department
Department of Molecular Neurobiology- Research Field
Biological sciences » Biology- Researcher Profile
First Stage Researcher (R1)- Country
Poland- Application Deadline
8 Mar 2024 - 23:00 (Europe/Brussels)- Type of Contract
Temporary- Job Status
Full-time- Hours Per Week
40- Is the job funded through the EU Research Framework Programme?
Not funded by an EU programme- Reference Number
5/2024/ICHB/PSD- Is the Job related to staff position within a Research Infrastructure?
No
Offer Description
KEYWORDS: neurodegenerative disease, brain, spinocerebellar ataxia 3, mutant protein, PolyQ, autophagy, proteasome, therapy, small molecules, preclinical drug testing, small molecule drugs
Principal Investigator: Maciej Figiel
Research topic: Investigation of a new therapeutic strategy to lower mutant protein in SCA3 / MJD
I. Project description
Neurodegenerative diseases, including polyglutamine diseases and Alzheimer's disease, are currently incurable. Spinocerebellar ataxia type 3 (SCA3) is a model example of a genetic neurodegenerative disease and is caused by a particular type of mutation that results in an increased number of CAG nucleotide repeats in the ATXN3 gene sequence. This mutation results in the defective ataxin-3 protein developing new toxic functions, forming toxic aggregates in the cell and disturbing several cellular processes. Ataxin-3 plays a crucial role in controlling which proteins and organelles should be cleared in the cell through two related cellular mechanisms called autophagy and UPS. Ataxin-3 recognizes a protein tag called ubiquitin that directs a protein or cell fragment for breakdown and detaches this tag from the protein, thereby preventing premature removal of the proteins from the cell. We aim to utilize molecule drugs to facilitate the controlled removal of toxic mutant ataxin-3 protein, preventing altered cellular processes that result in neurodegeneration in the brain cells of model animals. Our preclinical study using the SCA3 mouse model will test the small molecular drugs in the brain to develop a therapy targeted against toxic proteins, fighting neurodegeneration.
Additional information:
Requirements
- Research Field
- Biological sciences » Biology
- Education Level
- Master Degree or equivalent
Skills/Qualifications
Additional Information
Benefits
Ph.D. students shall receive a stipend in the gross amount of ca 4300 PLN (3800 PLN net)
II. Requirements for the candidates:
Selected skills, knowledge of which may be helpful:
III. Duties in the project:
IV. Required documents:
https://psd-ipan.ichb.pl/wp-content/uploads/2023/05/ICHBApplication_for_admission_10_05_23.docx
https://nawa.gov.pl/en/recognition/recognition-for-academic-purposes/applying-for-admission-to-doctoral-studies
V. Applications should be submitted via the eRecruiter portal at:
https://system.erecruiter.pl/FormTemplates/RecruitmentForm.aspx?WebID=671d6f0531a047959fbd53edf0b5529f
VI. Submission deadline is 08.03.2024
VII. Criteria for evaluation of candidates:
Eligibility criteria
VIII. The recruitment procedure shall be concluded no latter than 08.04.2024
IX. The description of the recruitment process is stipulated in the Regulations of Recruitment for PDS IPAS. Following the recruitment procedure, the unadmitted candidates shall be informed of the number of points obtained at both stages.
Incomplete applications will not be considered.
For additional information, please contact the Principal Investigator:
Maciej Figiel
e-mail: [email protected]
Information clause:
Pursuant to the stipulations of the regulation (EU) 2016/679 of the European Parliament and of the Council of 27 April 2016 on the protection of natural persons with regard to the processing of personal data and on the free movement of such data, and repealing Directive 95/46/EC (General Data Protection Regulation), further referred to as GDPR, we hereby inform that:
- The Institute of Bioorganic Chemistry, Polish Academy of Sciences, seated in Noskowskiego St. 12/14, 61-704 Poznan; REGON 000849327, NIP 777-00-02-062 is the administrator of the collected personal data (further referred to as the Institute).
- The Administrator appointed a Data Protection Officer, who can be contacted in writing, via traditional mail, by sending a letter to the following address: Z. Noskowskiego St. 12/14, 61-704 Poznan, or by sending an e-mail to: [email protected] .
- The personal data of the candidates is processed for the purposes of fulfilling the tasks of the administrator, associated with conducting the recruitment procedure for a vacant position.
- The legal basis for processing personal data is the Act of 26 June 1974 – The Labor Code, Act of 30 April 2010 on the Polish Academy of Sciences or the consent of the person whose data shall be subjected to processing.
Selection process
- Your personal data shall be subjected to processing for a period of 3 months upon the date of the decision of the recruitment committee. Following this period, the data will be irretrievably and effectively destroyed.
- The personal data of the candidates shall not be transferred to any third country.
- The person whose data shall be subjected to processing has the right to:
- request access to his/her personal data, and to amend it or delete it, pursuant to articles 15-17 of GDPR;
- limit data processing, in the events stipulated in article 18 of GDPR;
- data transferring, pursuant to article 20 of GDPR;
- withdraw consent at any moment, without influencing compliance with the law of the processing that was executed prior to consent withdrawal;
- file a complaint to the Inspector General for Personal Data Protection.
Providing personal data in the scope stipulated in article 22 (1) of the Act of 26 June 1974 – The Labor Code is mandatory, whereas providing data in a broader scope is voluntary and requires consent for its processing.
Work Location(s)
- Number of offers available
- 1
- Company/Institute
- Institute of Bioorganic Chemistry, PAS
- Country
- Poland
- State/Province
- wielkopolska
- City
- Poznań
- Postal Code
- 61-704
- Street
- Zygmunta Noskowskiego 12/14
- Geofield
Where to apply
- Website
https://system.erecruiter.pl/FormTemplates/RecruitmentForm.aspx?WebID=671d6f053…
Contact
- State/Province
wielkopolska- City
Poznan- Website
http://www.ibch.poznan.pl- Street
Noskowskiego 12/14- Postal Code
61-704
[email protected]
STATUS: EXPIRED
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