PHD Student no. 45/2022/ICHB/PSD

Institute of Bioorganic Chemistry Polish Academy of Sciences, Poland

Updated: over 1 year ago
Job Type: FullTime
Deadline: 15 Dec 2022

KEY WORDS: microsatellite sequences, CAG repeat instability, DNA repair, polyglutamine diseases,

Principal Investigator: Marta Olejniczak, PhD, professor of IBCH PAS

Website of Department of Genome Engineering: https://portal.ichb.pl/department-of-genome-engineering/

Research topic: Investigation of the mechanisms of short tandem repeats instability

I. Project description

The aim of this project is to better understand the mechanisms of CAG repeat instability and to identify new therapeutic targets that can be used for safe and controlled repeat shortening. We plan to achieve these goals through the following tasks: (1) identification of genes and cellular processes involved in CAG repeat instability, (2) validation of the participation of selected genes / pathways in the repeat instability process, (3) analysis of factors affecting CAG repeat instability (genetic context and cell type) and (4) controlled shortening of CAG repeats in a Huntington's disease mouse model.

ICHB PAN is one of the leading research units in Poland and conducts research activities in the field of chemistry, molecular biology and biomedicine. The Institute provides access to technologically advanced research equipment.

Additional information:

  • Research will be carried out within the 2021/43/B/NZ2/01615 OPUS 22 project, entitled “Searching for new therapeutic targets in polyglutamine diseases”, funded by National Science Centre.
  • PhD students shall receive a stipend in the gross amount of approx. 4300 PLN (approx. 3800 PLN net), for the period of 40 months (with the possibility of extension).
  • PhD students shall be subject to social insurance, pursuant to article. 6 section 1 passage 7b of the act of October 13th, 1998 on the social insurance system (Journal of Laws of 2019, item 300, 303 and 730).

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