In the Structural Biology Group, we study the structure and function of proteins using structural biology methods such as protein crystallography and electron microscopy, bioinformatics analysis and molecular dynamics simulations, as well as by functional assays both in vitro and in cell culture. Our newest project funded by an OPUS grant from the National Science Centre, Poland regards the role of antiviral proteins from the IFIT family in immune cells, and will combine the use of molecular, cell and structural biology and RNA-based therapies.
We are looking for a PhD student to work in the OPUS project on the role of IFIT2 complexes in the immune regulation in macrophages. The project aims to discover post-transcriptional mechanisms that regulate expression of cytokines at the first contact of immune cells with a pathogen. Our findings may have an impact on the diagnosis and treatment of autoimmune diseases or acute inflammatory reactions such as the "cytokine storm" accompanying COVID-19 morbidity.
Work in the project will include:
cloning, mutagenesis, DNA, RNA and protein purification and further manipulation using standard molecular techniques (e.g. PCR, qPCR, Western blot), protein-RNA interaction studies in vitro
cell culture, protein-RNA interaction studies in cell culture, antiviral and cytokine response assays, construction and characterization of cell lines, eCLIP and RNA sequencing.
Master’s Position Available To Study The Role Of The Unfolded Protein Response (Upr) During Spinal Cord Injury – Lindsey/Logue Labs, University Of Manitoba, Canadian Association for Neuroscience, Canada, about 11 hours ago
Description of the position: This project uniquely investigates the role of the unfolded protein response (UPR) in regulating the regenerative ability of neural stem cells following spinal cord in...
Ph D Position In Dynamic Single Cell Analysis (1.0 Fte), University of Groningen, Netherlands, 3 days ago
Applications are invited for a 4-year PhD study, starting as soon as possible, in the research group of Prof. Matthias Heinemann, (https://www.heinemannlab.eu) at the Groningen Biomolecular Scienc...
Ph D Position In Cellular Protein Biochemistry , Technical University of Munich, Germany, about 15 hours ago
28.04.2022, Wissenschaftliches Personal A PhD position is available in the laboratory for Cellular Protein Biochemistry at the Technical University of Munich (TUM) Department of Chemistry and Inst...
Post /Doctoral Position / Computational Scientist (Open Rank) In Experimental Neuroimmunology , University of Basel, Switzerland, 5 days ago
Why does the immune system attack the nervous system and what role do bacteria in our gut play in causing brain inflammation? If you are curious and motivated to decipher functional immune cell di...
Ph D In Protein And Rna Structural Changing During The Eukaryotic Cell Cycle, University of Groningen, Netherlands, about 5 hours ago
PhD in Protein and RNA structural changing during the eukaryotic cell cycle (222179H) « Back to the overview Job description Applications are invited for a 4-year PhD study, starting as soon as po...
Postdoctoral Position (100%, Funded) In Skeletal Muscle Plasticity (Group Of Prof. Christoph Handschin, Biozentrum/University Of Basel) , University of Basel, Switzerland, about 9 hours ago
Your position The Handschin group is interested in investigating the molecular, cellular and systemic processes that control skeletal muscle plasticity in health and disease. We are currently loo...