Project title: Self- or a directing group-aided remote C(sp3 )-H functionalization of difunctional compounds
Job description: The announced research project, funded by Polish National Science Center, is devoted to develop novel methods for self- and a directing group aided C(sp3 )-H functionalization of simple bi- and polyfunctional organic molecules. Most of the efforts will be put on the development mild and versatile protocols under modern radical photoredox or electrochemical conditions. Previous experience with organic photochemistry and/or electrochemistry will be an additional asset.
The PhD candidate (PDC) will be responsible for synthesizing, depositing, and characterizing of the starting materials and intermediates, followed by an optimization of reaction conditions for model transformations of radical initiated remote C(sp3 )-H functionalization of bi- and polyfuntional organic compounds. In extension, the PDC will investigate a scope of the developed protocols, including starting material variations, reaction condition variation (photoredox, electrochemical, transition-metal catalyzed process). Key efforts will be put on an investigation of asymmetric mode of the investigated C-H functionalization along with application studies devoted to synthesis of the selected bioactive or medicinally important molecule by using investigated process. Complementary theoretical studies on reaction mechanisms may be performed by the PDS or as part of a collaboration, depending on the scholar’s interests. To a certain degree, the PDC will be given intellectual freedom in defining their research.
The PhD candidate will also participate in the Institute scientific life by attending to group and institute seminars and lectures. The PhD candidate will also attend to advanced course devoted to modern organic chemistry and spectroscopy.
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