PhD student

Our research is focused on understanding the mechanisms of dynamic histone; DNA and RNA modifications in embryo development and cancer. These mechanisms, also known as epigenetic and epitranscriptomic regulation, have profound effect on the development of an organism and the differentiation of normal cells to cancer cells. In particular, recent pioneering work in the field of RNA regulation and novel methodology for analysing single cells enables novel studies on valuable biological material.

Oslo University Hospital is a workplace with great diversity. We believe this is absolutely crucial to solving the tasks required of us. We therefore want this diversity to be reflected among the applicants for our positions and encourage everyone to apply regardless of who you are and what background you have.

• Knowledge of basic methods in molecular biology (cell culture) and/or embryology are essential.
• Also required is experience with at least one of the following research areas: Histone modifications, RNA biochemistry methods (including PAR-CLIP, RIP-seq, and RNA-seq), RNA biology, genome stability, knock-down/overexpression systems, Crispr-Cas9 based engineering, embryology and bioinformatics.
• Potential candidates have recently completed a Master degree in molecular biology using methodology relevant for the techniques described above. Interested persons should submit the following documents:
• 1) A concise application letter explaining your motivation for this position (up to one page).
• 2) Curriculum vitae including a list of any peer-reviewed publications.
• 3) Contact information of three relevant references.

We are looking for an enthusiastic and determined candidate who can work both independently as well as in a group setting. The successful candidate is capable of conceptual thinking, is looking forward to learning new techniques, has good communication skills and is well organized.

The position will commence as soon as possible and will extend over 3 years with an evaluation period of 3 months.

A selection committee will announce the candidates two weeks after the closing deadline for interviews. Oslo University Hospital is an equal opportunity employer.

The position is sponsored by The Norwegian Research Council.

Relevant recent Publications:

Jin et al (2021) N6-Methyladenosine (m6A) Depletion Regulates Pluripotency Exit by Activating Signaling Pathways in Embryonic Stem Cells. PNAS 118:e2105192118

Abakir et al (2020) N6-methyladenosine regulates the stability of RNA:DNA hybrids in human cells Nature Gen 2020:52:48–55

Li, Zhao et al (2018) Ythdf2-mediated m6A mRNA clearance modulates neural development in mice. Genome Biol. 2018:19:69

Dahl, et al (2016) Broad histone H3K4me3 domains in mouse oocytes modulate maternal-to-zygotic transition. Nature 2016 537:548-552

Klungland et al (2016) Reversible RNA modifications in meiosis and pluripotency. Nature Meth 14:18-22

Zheng et al (2013) ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility. Mol Cell 49:18-29.