Unique dual track for PhD position in proteomics and junior scientist position at a start-up biotech company Sculpt BV

Promotion at University of Groningen

Promotor: Prof Dr Thomas Cremers

Type of promotion: external, position as junior scientist at Sculpt BV during your PhD with growth perspectives afterwards.

Companies involved: Sculpt BV, Combray BV, CAN holding BV, IQ products

Institutes involved: University of Groningen

In the last decades, several new mass spectrometry techniques have been developed to measure a broad spectrum of proteins, metabolites, and lipids in biological samples, resulting in the detection of  thousands of different analytes within a single sample. These approaches enable the discovery of new biomarkers and pathological imbalances with an unbiased approach. A challenge with these shotgun metabolomics, proteomics and lipid omics analyses is the variation between measurements.

The current project aims to further study and reduce the variation in shotgun approaches. By improving on sample preparation techniques, analytical conditions and data processing algorithms, a reduction in analytical variation is accomplished leading to a superior predictive value of the analyses. These new analytical conditions will lead to major improvements in clinical diagnostics.

Additionally, to working on your PhD thesis, you will become a full member of our bio-analytical team. After initial training, the candidate will be responsible for the development and application of bioanalytical assays for our clients. This project is a unique opportunity to obtain your PhD degree and gain inside into the biotech industry and start-up environment in life sciences together with seasoned start up veterans.

Responsibilities:

•Develop, optimize, and execute analytical separations, mass spectrometry and quantification of small molecules LC-MS/MS.

•Provide untargeted and targeted metabolomics for the project and collaborators.

•Develop novel technologies to expand the scope of services offered.

•Present results during internal and external meetings.

•Large dataset analysis and reporting

Your profile:

•You are a highly motivated, creative, and proactive PhD student, a team player able to work independently, eager to communicate and acquire and transfer knowledge.

•MSc. in chemistry, biochemistry, pharmacology, or related field

•Practical approach to troubleshooting and method development

•Hands-on experience with small molecule analysis are preferable and/or knowledge of Proteomics and/or other (High Res) LC/MS applications

•Your oral and writing communication skills in English are excellent and can present ideas clearly and concisely. 

•Must be authorized to work in the Netherlands without sponsorship.

About Sculpt BV:

Sculpt is a startup company that develops and performs proprietary bio analytical studies, enabling our clients unsurpassed insight in new biomarkers and biological mechanisms. The company is owned and run by a team of serial entrepreneurs with a proven track record of successful startups.

Terms: 

You will be employed based on a 36-hour week. Appointment is for 1 year, and will be extended for, when functions satisfactory. Salary is according to the general regulations gross € 3000 per month, 

How to apply:

For more information or application, please send your email, including your motivation and CV, to [email protected] . Make sure to do this before 01-04-2023. Clearly state the vacancy in the subject line.