Open PhD position at the Tissue Biology Research Unit of the University of Zurich on the role of macrophages on vascularization and regeneration of human skin. The position is part of the Innovative Training Network "SkinTERM ", Skin Tissue Engineering and Regenerative Medicine, an EU Horizon 2020 Marie Skłodowska-Curie Actions funded project. This network will train a new generation of entrepreneurial, multidisciplinary and intersectorially scientists able to drive this research area further towards clinical translation in Europe.
Project description
Macrophages play key roles in all phases of wound healing. Therefore, in this project, we want to investigate the role of distinct types of macrophages on the vascularisation and the healing response of bio-engineered human skin, in order to propagate a pro-healing macrophage response and scar-free skin tissue regeneration. Three main objectives for this project are:
- Preparation of skin grafts and polarisation of macrophages. The ESR will generate human dermo-epidermal skin grafts. Human classically activated, inflammatory macrophages (M1) and alternatively activated, tissue repair macrophages (M2), where two types of M2 macrophages will be investigated.
- Investigation of the influence of skin grafts with macrophages on their in vitro and in vivo behaviour. Keratinocytes, fibroblasts, endothelial cells and macrophages will be included in the dermal compartment of the human skin graft. Analyses will be undertaken on pre-vascularised grafts, both in vitro and in vivo after transplantation on immuno-deficient rats. For the in vitro analysis, focus will lie on the impact of differently polarised macrophage subsets on dermal capillary formation.
- In vitroscreening for novel skin pro- and anti-fibrotic factors secreted by different macrophage subsets. From Objective 2, we will learn which macrophage subsets lead to an anti-fibrotic, non-scarring response. In this objective, we will identify anti-fibrotic factors secreted by those macrophages in vitro.
Similar Positions
-
Ph D Candidate Biopsychosocial Factors In Chronic Skin Conditions, Leiden University, Netherlands, about 15 hours ago
Apply now PhD Candidate Biopsychosocial factors in chronic skin conditions In the Netherlands, over 2.5 million individuals suffer from chronic inflammatory skin diseases (e.g., psoriasis, atopic ...
-
Ph D Position In Discovery Of Novel Biomarkers For Chronic Wound Formation, Empa, Switzerland, 3 days ago
Materials science and technology are our passion. With our cutting-edge research, Empa's around 1,100 employees make essential contributions to the well-being of society for a future worth living....
-
Fully Funded Epsrc And Rcnde Ph D Scholarship: Real Time Tracking Of Cognitive Load To Assess Human Factors During Inspections , ; Swansea University, United Kingdom, 20 days ago
Funding providers: Engineering and Physical Sciences Research Council (EPSRC) and RCNDE Subject areas: Human-Computer Interaction, Machine Learning Project start date: 1 October 2024 (Enrolment op...
-
Ph D Student In Chemokine Immunobiology , Uppsala University, Sweden, 1 day ago
Published: 2024-03-28 PhD student in chemokine immunobiology - HORIZON-MSCA-2022-DN Doctoral Network “B-ACTIVE” These projects, funded by the Marie Skłodowska-Curie Actions (MSCA)-doctoral networ...
-
Ph D On New Microfluidic Designs For Continuous Sweat Analysis Within Textiles, Eindhoven University of Technology, Netherlands, 1 day ago
Irène Curie Fellowship No Department(s) Mechanical Engineering Reference number V35.7365 Job description Sweat analysis has emerged as a promising avenue for non-invasive monitoring of athlete per...
-
Ph D Candidate (M/F/D): Bioimaging, Leibniz, Germany, 1 day ago
The Leibniz-Institut für Analytische Wissenschaften - ISAS - e. V. develops efficient analytical methods for health research. Thus, it contributes to the improvement of the prevention, early diagn...