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Help us uncover how the infant gut microbiome shapes immune development. Join Us! Do you want to investigate how the microbiome acquired in early life influences innate immunity and pathogen
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. The position is part of the ERC Starting Grant project ACTIN in ACTION, which investigates the molecular mechanisms of actin-based motility in the intracellular bacterial pathogens Shigella and Listeria
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of actin-based motility in the intracellular bacterial pathogens Shigella and Listeria. These pathogens use the surface proteins IcsA and ActA to recruit host actin-regulatory factors and generate actin
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of pathogen effectors and plant immune receptors is key to understanding disease resistance. We use a diverse collection of wild Solanum species to identify and characterize immune receptors involved in
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recruitment, metabolite-mediated interactions, pathogenicity and disease resistance. This will involve using and further adapting state-of-the-art genome mining approaches, including biosynthetic gene cluster
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how ERAP2 shapes pathogenic immune responses and if this can be corrected with small molecular inhibitors. This project aims to test whether targeting ERAP2 can selectively remove pathogenic EBV
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at the forefront of plant immunity, effector biology, and sustainable crop improvement. The molecular interaction of pathogen effectors and plant immune receptors is key to understanding disease resistance. We use a