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. These pathogens use the surface proteins IcsA and ActA to recruit host actin-regulatory factors and generate actin comet tails that propel the bacteria through infected cells. The successful candidate will combine
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You will establish an anaerobic gut-microbiome-on-a-chip platform tailored to the human infant gut and investigate how early colonisation by commensal bacteria or pathobionts affects the development and
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comet tails that propel the bacteria through infected cells. The successful candidate will combine biochemical reconstitution, fluorescence microscopy and structural biology to determine how this process
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