7 human-tracking-"https:"-"https:"-"https:"-"https:" PhD positions at Amsterdam UMC in Netherlands
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unique expertise in human neuropathology. The team has extensive experience with human tissue, histology, cell culture, microscopy and advanced molecular techniques, including transcriptomic analyses
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for human CAA. You will investigate whether the blood-brain barrier is disrupted in this model and whether interventions targeting the blood-brain barrier influence the course of CAA. You will use a
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applications. By tracking ^89Zr-labelled cells over extended periods of up to one month, you will investigate immune cell homing and trafficking, generating new insights into disease mechanisms and the potential
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. You will use human in vitro models, including astrocytes and brain organoids generated from induced pluripotent stem cells (iPSCs) of people with MLC and healthy controls. You will investigate disease
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physiologically relevant human in vitro model of Pelizaeus-Merzbacher-like disease type 1 (PMLD1). You will first test leading AAV capsids developed by Myrtelle Therapeutics Inc. in the in vitro model. You will
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liquid biomarkers for leukodystrophies by integrating multi-omics data from patient plasma and iPSC-derived human disease models. You will investigate disease-related molecular signatures using
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, for example through newborn screening, family screening or genetic testing. These families may face uncertainty about when symptoms will develop and difficult decisions about treatment. Understanding