9 decision-making-"https:"-"https:"-"https:"-"https:"-"https:" PhD positions at Amsterdam UMC in Netherlands
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You will contribute to a translational research project aimed at improving the diagnosis and treatment of coronary artery disease and supporting clinical decision-making during catheterization
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, resilience research and digital quality-of-life assessment. Leukodystrophies can have a profound and long-lasting impact on patients and their families. Yet current quality-of-life measures do not adequately
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vivo characterisation of the generated nanobodies, including assessment of their affinity, specificity, modulatory effects, stability and biodistribution. Through the POLARIS network, you will also gain
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assess their effects on myelination and oligodendrocyte survival. The most promising oligodendrocyte-targeting AAV variants will subsequently be tested in a PMLD1 mouse model to determine their therapeutic
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. Through planned secondments, you will gain experience in omics research, biomarker development and patient engagement. You will have the opportunity to shape the focus of your research according to your
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cell-based disease modelling, neuroscience and translational research. Through planned secondments, you will also gain experience with MLC animal models and computational chemistry approaches
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secondments will broaden your expertise through hands-on training in lipid nanoparticle delivery. You will also have opportunities to engage with patients and families to better understand leukodystrophies and
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. Throughout the PhD project, you will have opportunities to further develop your scientific and transferable skills through the POLARIS doctoral training programme.
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of the POLARIS training programme, you will undertake planned secondments that complement your research at the University of York. At Zantiks , you will gain hands-on experience with behavioural