Postdoc position in mass spectrometry and proteomics (1.0 FTE)

Updated: about 1 month ago
Job Type: Temporary
Deadline: 25 Feb 2021

In recent years we have developed new proteomics methods ranging from improved separation and enrichment methodologies to new fragmentation techniques and targeted analysis of post-translation modifications (PTMs). These improvements enable us to decipher the complexity of the human proteome, consisting of dynamic protein-protein interactions, PTMs, protein synthesis and degradation, protein complex assembly and disassembly, etc. To further advance the impact of our proteomics tools in the biological and clinical setting, smooth integration with other omics technologies such as genomics and metabolomics is a prerequisite.

For this position, we seek a highly motivated Biochemist or Analytical Chemist with proven expertise in mass spectrometry and proteomics. Having your own project, you will team-up with dedicated Researchers combining expertise in biochemistry, analytical chemistry, mass spectrometry, and bioinformatics to further develop state-of-the-art proteomics methods that will answer pressing biological questions. As part of the Netherlands X-omics Initiative, you will interact and collaborate with national and international Researchers to enable the efficient integration of proteomics data and workflows with other omics technologies and enable the translation of the integrated X-omics datasets into biologically relevant information.

Recent illustrative work

  • Kleinpenning F, et al. (2020) Fishing for newly synthesized proteins with phosphonate-handles. Nature Communications 11(1), 3244.
  • Schmidlin T, et al. (2019) High-Throughput Assessment of Kinome-wide Activation States. Cell Systems 9(4):366-374.
  • Ressa A, et al. (2018) A System-wide Approach to Monitor Responses to Synergistic BRAF and EGFR Inhibition in Colorectal Cancer Cells. Molecular & Cellular Proteomics. 17(10), 1892-1908.

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