PhD student: unraveling the radiation biology of radioactive anticancer agents

29 Mar 2024
Job Information

Organisation/Company

Erasmus MC (University Medical Center Rotterdam)

Research Field

Medical sciences

Researcher Profile

First Stage Researcher (R1)

Country

Netherlands

Application Deadline

10 Apr 2024 - 22:00 (UTC)

Type of Contract

Temporary

Job Status

Not Applicable

Hours Per Week

36.0

Is the job funded through the EU Research Framework Programme?

Not funded by an EU programme

Is the Job related to staff position within a Research Infrastructure?

No

Offer Description

We are looking for a highly motivated PhD student to work on a project focusing on the radiation biology of targeted radionuclide therapy (TRT). This multidisciplinary project brings together expertise from the fields of nuclear medicine, molecular biology and cellular (radiation) biology.

TRT is a promising novel modality to treat patients with metastasized cancer. TRTs function via systemic administration of radiolabeled molecules designed to target tumor cells. However, the biological radiation effects of TRTs are poorly understood, and rational design of new modalities based on underlying cellular mechanisms is therefore not possible, resulting in suboptimal treatment strategies. In this preclinical research project, you will perform cellular experiments to identify and quantify specific radiobiological mechanisms of TRT-radiation effects.

In this project, you will be trained in using various laboratory techniques including cell culture, (fluorescent) microscopy, and different molecular biological techniques. Focus of this project will be on 2D cellular model systems and within the consortium, you will collaborate with colleagues from Radboud UMC who will work on 3D and in vivo radiobiology.

Requirements
Specific Requirements

• You are a highly motivated and talented candidate that holds a MSc degree in Biomedical Science, Molecular/Cellular Biology, Oncology, or related field with a basic knowledge on radionuclide/radiation treatments and/or the DNA damage response.
• Experience with standard molecular biology techniques, microscopy and/or radionuclide handling will be considered an advantage.
• You are a team-player who is able to combine independent thinking with a collaborative attitude as you will be working in a dynamic international research environment.
• You have strong written and oral English skills (EUR requirements minimum IELTS overall score of 7.0 [comparable to TOEFL PBT: 600; TOEFL CBT: 250; TOEFL IBT: 95]).

Additional Information
Benefits

• You will receive a temporary position for 4 years. The gross monthly salary is € 2.901,- in the 1st year and gradually increases to € 3.677,- in the 4th year (scale OIO).
• Excellent fringe benefits, such as a 13th month that is already paid out in November and a individual travel expense package.
• An International Office which aids you in preparing for you arrival and stay.
• Pension insurance with ABP. We take care of approximately 2/3 of the monthly contribution.
• Special benefits, such as a incompany physiotherapist and bicycle repairer. And there is also a gym where you can work on your fitness after work.

Selection process

For more information about this position, please contact Julie Nonnekens, associate professor and group leader, via [email protected] .

Additional comments

For more information about this position, please contact Julie Nonnekens, associate professor and group leader, via [email protected] .

Website for additional job details

https://www.academictransfer.com/339645/

Work Location(s)

Number of offers available

1

Company/Institute

Erasmus MC

Country

Netherlands

City

Rotterdam

Postal Code

3015 GD

Street

Dr. Molewaterplein 40

Where to apply

Website

https://www.academictransfer.com/en/339645/phd-student-unraveling-the-radiation…

Contact

City

Rotterdam

Website

http://www.erasmusmc.nl/

Street

Dr. Molewaterplein 40

Postal Code

3015 GD

STATUS: EXPIRED