PhD student

1 Mar 2024
Job Information

Organisation/Company

University Medical Centre Groningen (UMCG)

Research Field

Medical sciences

Researcher Profile

Recognised Researcher (R2)
First Stage Researcher (R1)

Country

Netherlands

Application Deadline

18 Mar 2024 - 23:00 (UTC)

Type of Contract

Temporary

Job Status

Not Applicable

Hours Per Week

36.0

Is the job funded through the EU Research Framework Programme?

Not funded by an EU programme

Is the Job related to staff position within a Research Infrastructure?

No

Offer Description

Are you interested in unraveling the underlying mechanisms causing leukemia and keen to further develop our understanding of leukemia biology in order to ultimately improve patient care? We currently have a PhD position available at the Department of Hematology in the UMCG, focusing on the molecular mechanisms in nucleophosmin (NPM1) mutated acute myeloid leukemia.

The current project is funded by the Dutch Cancer Society and aims to dissect the pathogenesis of NPM1-mutated AML, in order to ultimately improve therapy. NPM1 is one of the most frequently
mutated gene in AML. While the clinical relevance of NPM1 mutations in AML is well established, the biological mechanisms by which NPM1 mutations exert their oncogenic functions are poorly understood. We will investigate the effect of NPM1 mutations on the process of protein translation, using polysome profiling studies and RNA sequencing. Further, altered nuclear transport processes and protein quality control mechanisms in NPM1 mutated AML will be subject to our investigations, using patient-derived AML cell cultures and detailed molecular studies.

Requirements
Specific Requirements

- MSc degree in biomedical/life-sciences related subject
- Excellent English writing and presenting skills
- A strong team player, but also the ability to work independently
- Experience in cell biological techniques (e.g. eukaryotic tissue culture) is required
- Experience in molecular biology techniques such as Western Blotting, molecular cloning, retroviral/lentiviral transduction protocols, sequencing is desirable
- You are highly motivated and eager to advance our understanding of leukemia

The UMCG has a preventive Hepatitis B policy.

Additional Information
Benefits

- A fulltime contract for 1 year, which will be extended for 3 years after evaluation
- A salary of € 2.901,- in the first year to a maximum of € 3.677,- gross per month in the final year (PhD salary scale), based on a fulltime contract
- A holiday allowance of 8% gross annual income and an 8.3% end of the year bonus
- The conditions of employment comply with the Collective Labour Agreement for Medical Centres (CAO-UMC).

Selection process

dr. Carolien Woolthuis, [email protected] , telefoonnummer: (050)36 15 986

Additional comments

dr. Carolien Woolthuis
(050)36 15 986
[email protected]

Website for additional job details

https://www.academictransfer.com/338415/

Work Location(s)

Number of offers available

1

Company/Institute

University Medical Center Groningen (UMCG)

Country

Netherlands

City

Groningen

Postal Code

9713 GZ

Street

Hanzeplein 1

Geofield

Where to apply

Website

https://www.academictransfer.com/en/338415/phd-student/apply/#apply

Contact

City

Groningen

Website

http://www.werken.umcg.nl/

Street

Hanzeplein 1

Postal Code

9713 GZ

STATUS: EXPIRED