(Macro)autophagy is a conserved catabolic pathway that mediates lysosomal turnover of defective or excess intracellular structures, including protein complexes and organelles. The structures targeted to destruction are sequestered into double-membrane autophagosomes and delivered into lysosomes. In addition to eliminate cytoplasmic components in a random manner, autophagy can be highly selective by recognizing specific cargo via the so-called autophagy receptors. Types of selective autophagy are key in fine regulating a multitude of physiological functions, including cell differentiation and metabolism. Within this interdisciplinary collaborative project, we aim at providing a comprehensive mechanistic view about how selective autophagy is regulating metabolism during the adaptation to specific nutritional changes. This study will be initially performed in yeast Saccharomyces cerevisiae, before we will transfer key principles to cancer cells.
You are expected to conduct a research project, involving a combination of yeast genetics, cell biology, biochemistry (including proteomics and metabolomics), molecular biology, and live-cell imaging, embedded within the research group of Prof. Fulvio Reggiori.
The position is supported by the Sinergia program of the Swiss National Science Foundation (SNSF) and it is for four years, with a one-year trial period.
Interdisciplinary Ph D Position In Quantitative Cell Biology And Biochemistry, University of Groningen, Netherlands, about 13 hours ago
We are looking for a highly motivated and enthusiastic PhD candidate with a strong background in cell biology, (bio)chemistry, (bio)physics or closely related fields to join the Cell Cycle Dynamic...
Ph D / Post Doc In Biophysics , Technical University of Munich, Germany, about 13 hours ago
03.05.2021, Wissenschaftliches Personal Living cells rely on the ability of the cytoskeleton to continuously form and destroy diverse structures, which is strongly coupled to the adhesion processe...
Ph D Position: Transcriptional Regulation And Functional Validation Of Endo Lysos, University Medical Centre Groningen (UMCG), Netherlands, about 13 hours ago
Metabolic syndrome (MetS) is a collection of pathological conditions that include abdominal obesity, increased blood pressure, insulin resistance and increased blood glucose and lipids. MetS is a ...
Ph D Position , University of Zurich, Switzerland, about 17 hours ago
Gene therapy laboratory, Institute for Regenerative Medicine, University of Zurich PhD Position 100 % Institute for Regenerative Medicine (IREM) The gene therapy and immunology laboratory is associ...
Ph D On Electrokinetically Driven Microchips For Immuno Engineering, Eindhoven University of Technology (TU/e), Netherlands, about 13 hours ago
At the Department of Biomedical Engineering at Eindhoven University of Technology (TU/e), we currently have a vacancy for a postdoc in the field of microfluidics. To investigate the crosstalk betw...
Positions For A Ph D Student And A Research Technician In Molecular Cell Biology In Berlin (F/M/D), Leibniz, Germany, about 17 hours ago
We are seeking to recruit a PhD student and a research technician in molecular cell biology to study how osmotic stress and other stimuli regulate exo-/ endocytosis to control the biogenesis and f...