Key takeaways
About the project:
This project aims to take the concept of receptor recruitment from biology and use it as a design criterium for self-assembling building blocks into well-defined molecular and nanoscale architectures. Intrinsically weak and dynamic interactions are essential in achieving self-assembly and recruitment. Exquisite control over stoichiometry and structure of the assemblies is achieved by harnessing ground-breaking developments in the understanding of the underlying multivalent interactions. These breakthrough insights will be used to tackle challenges with the identification, sensing and isolation of biological particles, such as viruses and extracellular vesicles, through the development of platforms with nanoscale dimensions and molecular functionalities. As such, this project takes inspiration from nature, by borrowing recruitment as a concept to build self-assembled materials, and to contribute to a better understanding of living systems using new detection and isolation tools, with application prospects for biomedical platforms and smart materials.
PhD student positions are foreseen on these topics: Design and assembly of well-defined structures based on receptor recruitment; Fixation of recruiting self-assembling systems; Engineering of signaling functions in recruiting systems; Device platforms to count and isolate biological particles. The positions are part of the ERC Advanced project “Receptor Recruitment as an Organizational Principle for Self-Assembling Matter, RECRUIT”.
Information and application
Interested? Send your application before August 31, 2024 through the provided button and should include:
- transcript of your MSc course grades
- CV, including publication list (when applicable)
- motivation letter targeted to the project as a whole and/or one of the specific subprojects mentioned above
- contact info of at least two references.
The positions are available from December 1, 2024, the starting date is negotiable.
For more information (but no direct applications), you are encouraged to contact Prof. Jurriaan Huskens, [email protected] (website MNF: https://www.utwente.nl/en/tnw/mnf/).
About the department
The group of Prof. Jurriaan Huskens (website: https://www.utwente.nl/en/tnw/mnf/) is part of the Department of Molecules & Materials, of the Molecules Centre, of the research institutes MESA+ Institute and TechMed Centre, and of the Faculty of Science & Technology, University of Twente. The group hosts and has access to state of the art chemical, surface-chemical, surface analytical and nanotech facilities.
About the organisation
The Faculty of Science & Technology (Technische Natuurwetenschappen, TNW) engages some 700 staff members and 2000 students in education and research on the cutting edge of chemical technology, applied physics and biomedical technology. Our fields of application include sustainable energy, process technology and materials science, nanotechnology and technical medicine. As part of a people-first tech university that aims to shape society, individuals and connections, our faculty works together intensively with industrial partners and researchers in the Netherlands and abroad, and conducts extensive research for external commissioning parties and funders. Our research has a high profile both in the Netherlands and internationally and is strengthened by the many young researchers working on innovative projects with as doctoral candidates and post-docs. It has been accommodated in three multidisciplinary UT research institutes: Mesa+ Institute, TechMed Centre and Digital Society Institute.
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