4 Apr 2024
Job Information
- Organisation/Company
The Netherlands Cancer Institute- Research Field
Physics
Other
Medical sciences- Researcher Profile
Recognised Researcher (R2)
First Stage Researcher (R1)- Country
Netherlands- Application Deadline
3 May 2024 - 21:59 (UTC)- Type of Contract
Temporary- Job Status
Not Applicable- Hours Per Week
36.0- Is the job funded through the EU Research Framework Programme?
Not funded by an EU programme- Is the Job related to staff position within a Research Infrastructure?
No
Offer Description
The research group of Jacqueline Jacobs at the division of Oncogenomics aims to understand the processes that act to safeguard genome integrity but that, when working inappropriately, cause cells to become dysfunctional or die, or to get derailed and cancerous. More specifically, we aim to identify new factors and molecular mechanisms that are critical in telomere and genome maintenance through appropriate DNA damage responses, DNA replication, and DNA repair.
In this project we seek to achieve an increased mechanistic understanding of telomere maintenance in pediatric cancers, in particular via the alternative lengthening of telomeres (ALT) mechanism. Recent discoveries indicate that ALT is activated by defective DNA replication fork dynamics, which result in DNA breaks and increased recombination at telomeres. Given that ALT has a major impact on the survival of a considerable portion of pediatric cancers, and is not used by normal non-cancerous cells, it represents an attractive target for cancer treatment. However, the lack of comprehensive mechanistic understanding of ALT hampers therapeutic progress related to ALT. Therefore, in this multidisciplinary project, funded by the Children Cancer Free Foundation KIKA, we aim to increase understanding of the factors and molecular mechanisms that control ALT. For this we will follow-up on recent unpublished findings from our lab, that implicate new factors in the regulation of ALT. In addition, we will investigate how ALT regulation by these factors can be exploited in treatment of ALT-positive pediatric cancers.
Requirements
Specific Requirements
We are looking for an ambitious and enthusiastic PhD candidate with a strong commitment to science and solid background in molecular biology and cell biology. The candidate should be creative, highly self-motivated, capable of independent thinking, have a problem-solving attitude and be a very good experimentalist. Good communication skills (oral and written) and ability to work together with others in an international team are essential. Previous experience in the fields of telomere maintenance, DNA replication and/or DNA damage and repair, would be advantageous, but are not an absolute must.
Additional Information
Benefits
We offer a stimulating and interactive research environment, free use of all state-of-the-art facilities, a competitive salary. The gross salary per month can range from € 3.355,- to € 4.073,- (salary PhD scale, according to the Collective Labour Agreement General Hospitals), depending on your experience. In addition, you will receive 8,33% holiday pay and end-of-year bonus (8,33%). The appointment is for a period of four years. You will participate in the educational program of the Oncology Graduate School Amsterdam (OOA) that offers high-quality courses.
Your travel expenses will be reimbursed at € 0,19 per km. Free parking at the Antoni van Leeuwenhoek is also part of the package. Personnel is stimulated to use public transport and bicycle and therefore we offer an interesting arrangement for bikers and/or discount on the NS-business card.
Selection process
How to apply
Applications should include your CV, a motivation letter, your transcripts and contact information of at least 2 references, and can be submitted via the application button.
The NKI values diversity and is committed to creating an inclusive work environment that stimulates the best in each individual. Applications of all individuals are welcomed regardless of age, ancestry, religion, disability, distance from the labor market, sexual orientation or gender identity.
Additional comments
How to apply
For further information visit our website (https://www.nki.nl/research/research-groups/jacqueline-jacobs/ ) or contact Jacqueline Jacobs ([email protected] ). Applications should include your CV, a motivation letter, your transcripts and contact information of at least 2 references, and can be submitted via the application button.
The NKI values diversity and is committed to creating an inclusive work environment that stimulates the best in each individual. Applications of all individuals are welcomed regardless of age, ancestry, religion, disability, distance from the labor market, sexual orientation or gender identity.
- Website for additional job details
https://www.academictransfer.com/339785/
Work Location(s)
- Number of offers available
- 1
- Company/Institute
- The Netherlands Cancer Institute
- Country
- Netherlands
- City
- Amsterdam
- Postal Code
- 1066 CX
- Street
- Plesmanlaan 121
- Geofield
Where to apply
- Website
https://www.academictransfer.com/en/339785/phd-student-position-to-study-telome…
Contact
- City
Amsterdam- Website
https://www.avl.nl/- Street
Plesmanlaan 121- Postal Code
1066 CX
STATUS: EXPIRED
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