A PhD position for 4 years is available in the research group of Prof. Marcel van Vugt. The lab is focused on cell cycle regulation and DNA damage responses in cancer cells in relation to inflammatory signaling. The research group is embedded in the Department of Medical Oncology of the University Medical Center Groningen (UMCG) in the Netherlands, where oncological patient care is coordinated with preclinical and fundamental research on the biology and treatment of cancer. The Department of Medical Oncology participates in the Groningen Cancer Research Center (GCRC) graduate School of the University of Groningen, in which molecular biologists, pharmacists and clinicians work closely together creating an optimal and excellent environment where the biological behavior of cancer cells, molecular imaging of tumors and novel approaches of cancer targeting are studied.
Click here for more information on current research topics.
Background
A property of many cancers is defective genome maintenance. This is particularly prominent in triple negative breast cancer (TNBC). We have recently described that defective DNA repair in these cancers leads to inflammatory signaling. In order to escape clearance by the immune system, these tumor cells need to suppress inflammatory signaling. The current project aims to elucidate how cancers, in particular TNBC, can suppress inflammatory signaling, and if these mechanisms can be therapeutically targeted. This project is funded by a recently awarded grant from the Dutch Cancer Society (KWF), and will involve cell biological, biochemical, microscopy and genetic approaches. As part of this project, we will validate our findings in patient material. Of note, this project is part of a collaboration with the research group of Prof. Jos Jonkers at the Netherlands Cancer Institute.
Similar Positions
-
Ph D Position: The Clinical Utility Of Cancer Detection During Non Invasive Prenatal Screening, Katholieke Universiteit Leuven, Belgium, about 2 hours ago
(ref. BAP-2023-66) Laatst aangepast : 31/01/2023 Project Non-invasive prenatal screening (NIPS) is routinely offered to all pregnant women to screen for fetal trisomy 21. Analyses cell-free DNA (...
-
Ph D Position Super Resolution Visualisation And Control Of Cellular Dynamics, Delft University of Technology, Netherlands, about 7 hours ago
Would you like to contribute to groundbreaking research on establishing microscopy-guided automated real-time control of biological processes, as a PhD candidate? Then this might be the vacancy fo...
-
Ph D Position Super Resolution Visualisation And Control Of Cellular Dynamics, Delft University of Technology (TU Delft), Netherlands, 23 days ago
PhD Position Super-Resolution Visualisation and Control of Cellular Dynamics PhD Position Super-Resolution Visualisation and Control of Cellular Dynamics Published Deadline Location today 15 Feb D...
-
Ph D In Quantitative Cell And Developmental Biology, Leiden University, Netherlands, 3 days ago
Apply now The Faculty of Science / the Institute for Biology is looking for a : PhD in Quantitative Cell and Developmental Biology Vacancy number: 23-006 Key responsibilities The PhD project will ...
-
Doctoral (Ph D) Student Position In Chromatin Topology And Bioinformatics, Karolinska Institutet, Sweden, about 21 hours ago
To be a doctoral student means to devote oneself to a research project under supervision of experienced researchers and following an individual study plan. For a doctoral degree, the equivalent of...
-
Europe: 11 Ph D Positions In Msca Dn Project Rbp Regu Net, University of Santiago de Compostela (USC), Spain, 3 days ago
Eleven PhD positions are available in the Marie Sklodowska-Curie Doctoral Network “RBP-ReguNET – Deconstructing and Rewiring RNA-RBP regulatory networks”. RBP-ReguNet has been conceived to leverag...