PhD student on: Disentangling the Role of Intracranial Arteriosclerosis in Alzheimer’s Disease

Erasmus MC (University Medical Center Rotterdam), Netherlands

Updated: almost 2 years ago
Deadline: 05 May 2022

Vascular disease is an important risk factor for dementia, often contributing in conjunction with Alzheimer pathology (like amyloid and tau) to the clinical phenotype of Alzheimer's disease (AD). Yet, the exact role of vascular disease in brain health and the development of clinical AD, and its interaction with typical AD pathology, remains largely unknown. The current research project will provide insight into the role of arteriosclerosis - a hallmark of vascular disease - in AD, with a particular focus on the intracranial vasculature and the earliest form of disease, by using an innovative, population imaging-based approach.

The PhD-candidate will be working in the dynamic environment of the population-based Rotterdam Study, and will be involved in data-collection related to cognitive functioning and dementia and processing of CT-, and PET-imaging of the brain. The candidate will analyze the collected data in light of the specific research questions, and disseminate the findings through scientific articles and conference presentations. As part of the PhD-trajectory, the candidate will enter an Master of Science Programme in Health Sciences at the Netherlands Institute of Health Sciences (NIHES).


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