PhD student Molecular Pathology (targeting pro-tumorigenic fibroblasts in invasive lobular breast cancer)
The research group of Dr. Julia Houthuijzen is dedicated to investigating the biology of stromal cells in the breast tumor microenvironment. We aim to understand the origin, heterogeneity and impact of cancer-associated fibroblasts (CAFs) on tumor development, progression and therapy resistance.
Your main project will focus on:
1) In vivo lineage tracing of CAF precursors in breast cancer mouse models.
2) In vivo targeting of pro-tumorigenic processes in CAFs and assess their effects on tumor development and therapy response.
3) Single cell transcriptomics of human lobular breast cancer specimens to further investigate CAF-tumor cell crosstalk.
The research will take place within the group of Prof. Jos Jonkers at the department of Molecular Pathology. The Jonkers lab has expertise in modelling human breast cancer in genetically and somatically engineered mice and patient-derived tumor xenograft (PDX) models.
Responsibilities
You will collaborate with members of the group of Jos Jonkers and other collaborators inside the institute and abroad. The position involves experimental animal handling and surgeries, intervention studies in mice and wet lab skills like flow cytometry, primary cell culture, immunohistochemistry and single cell transcriptomics.
Similar Positions
-
Ph D Student Position In Blood Cancer Research , University of Basel, Switzerland, 21 days ago
The Department of Biomedicine (DBM) is a joint effort between the University of Basel and the University Hospitals Basel. It unites basic and clinical scientists to advance our understanding of he...
-
Multiple Ph D Positions On "Single Cell Proteome Profiling" , ETH Zurich, Switzerland, about 4 hours ago
100%, Zurich, fixed-term The laboratory of Single-Molecule and Single-Cell Biophysics (BMC) is a research group in the Department of Information Technology and Electrical Engineering (D-ITET) at E...
-
Ph D Position In Biotechnology, Slovak University of Agriculture in Nitra, Slovakia, 8 days ago
17 Apr 2024 Job Information Organisation/Company Slovak University of Agriculture in Nitra Department Faculty of Biotechnology and Food Science Research Field Agricultural sciences Researcher Prof...
-
Ph D Position In Biotechnology, Slovak University of Agriculture in Nitra, Slovakia, 8 days ago
17 Apr 2024 Job Information Organisation/Company Slovak University of Agriculture in Nitra Department Faculty of Biotechnology and Food Science Research Field Agricultural sciences Researcher Prof...
-
Ph D In Image Analysis And Data Modelling For Advanced Microscopy Applied To Biomolecular Systems (Barcelona), Universitat Pompeu Fabra, Spain, 29 days ago
27 Mar 2024 Job Information Organisation/Company Universitat Pompeu Fabra Department Department of Experimental and Health Sciences Research Field Biological sciences Physics Researcher Profile Le...
-
Ph D Positions On Cancer Cell Biology Medical University Innsbruck, Austria, Medical University Innsbruck, Austria, 12 days ago
12 Apr 2024 Job Information Organisation/Company Medical University Innsbruck Department Pathophysiology Research Field Medical sciences » Cancer research Researcher Profile First Stage Researcher...