ASD is a developmental disorder for which currently no general effective therapy exists. This project is part of a larger program “New, rational therapy decisions for developmental brain disorders: Integrating quantitative patient assessment, cellular assays and nanotechnology (NewTDec)”, and is among the first project to operate under the Dutch research agenda (www.wetenschapsagenda.nl ). NewTDec is a multidisciplinary consortium in which clinicians, neuroscientists, nanoscientists and patient organizations collaborate to develop new methods to identify biological causes for autism with the aim to develop personalized medicine for children with ASD. Quantitative assessment of brain functions using predictive EEG ‘signatures’ for individual patients and cellular assays using patient-own, stem cell-derived neurons will be used to measure specific brain characteristics in the same patient. This information is used in clinical trials to match patients with an optimal, individual therapy and to develop novel therapies for specific patient subgroups in the future.
In this project we will use patch-clamp electrophysiology to study synaptic transmission and neuronal function in networks from inducible pluripotent stem cells (IPSC's) derived neurons from children with ASD. We will specifically investigate cellular and synaptic parameters that affect the balance between excitation and inhibition (E/I) in these networks. One of the leading hypothesis is that E/I balance is disturbed in neurodevelopmental disorders such as ASD, leading to altered information processing in the brains of these patients. We will test if and how cellular and synaptic parameters are changed in patients that have been selected for a putative altered E/I balance, based on biomarkers obtained from their EEG profile. Furthermore, we will test how these parameters are affected by various E/I modifying drugs. This information will eventually be used to inform N=1 clinical trials in the same patients. You will be trained on site and in specialized courses on campus. During the PhD you will write several scientific publications that will be combined in a PhD thesis.
Postdoc Position: Therapeutic Targeting Of Pre Synaptic Tau, VIB, Belgium, about 8 hours ago
About the Lab The Verstreken Lab at the VIB-KU Leuven Center for Brain & Disease Research , Belgium, is seeking a highly motivated postdoctoral fellow to develop translational approaches that tar...
Ph D Position To Tackle Alzheimer’s Dementia By Targeting The Presynaptic Defects Induced By Tau, VIB, Belgium, about 8 hours ago
About the project We are looking for a highly motivated Ph.D. student for a joint project between the Verstreken and De Strooper labs, to develop mouse chimeric models and test the hypothesis that...
Ph D Student Position For The Project: Risk Factors For Alzheimer’s Disease, Katholieke Universiteit Leuven, Belgium, 20 days ago
Alzheimer’sdisease (AD) is a neurodegenerative disorder, which is characterized by specific pathological hallmark lesions. These lesions develop first in a limited area of the brain and then expan...
Ph D Position 'Oral Biology (Immunology, Microbiology, Cell Biology)', Vrije Universiteit Amsterdam, Netherlands, about 12 hours ago
On the occasion of ACTA’s Honorary Doctorate; “celebratory” PhD position in oral biology (immunology, microbiology, cell biology) to study the relations between oral health and systemic diseases, ...
Ph D Position In Oral Biology (Immunology, Microbiology, Cell Biology), University of Amsterdam, Netherlands, about 23 hours ago
The Academic Centre for Dentistry in Amsterdam (ACTA) is the collaboration of the Faculties of Dentistry at the University of Amsterdam and Vrije Universiteit Amsterdam. We focus on all aspects o...
Ph D Student (M/F/D), Leibniz, Germany, about 7 hours ago
The Bernhard Nocht Institute for Tropical Medicine (www.bnitm.de ) is the largest Research Institute for Tropical Medicine in Germany and is the National Reference Centre for Tropical Pathogens, a...