PhD Student: Efficacy of diagnostic and antimicrobial capacity of smart triggered release systems for medical devices in vivo

Academic Medical Center (AMC), Netherlands

Updated: about 2 months ago
Deadline: 27 Apr 2021

STIMULUS is a European Marie Curie Training Network working on reducing healthcare-associated infections. As an early-stage researcher (Ph.D. student) you will be trained for a career in biomaterials by research on smart triggered release systems that can detect, prevent and treat bacterial infections. The STIMULUS consortium unites academia, medical research institutes, policymakers and industry.

You can find more information on the STIMULUS consortium and on the selection process on the STIMULUS website at https://www.stimulus-etn.eu/

The diagnostic sensitivity, specificity, and performance for the detection of bacterial species and efficacy of novel antimicrobial systems will be evaluated in in vivo systems, in particular in mouse models of skin infection or subcutaneous implant infection. As a PhD student your main tasks and responsibilities are:

  • To tailor these models for testing of smart triggered release systems for their diagnostic capacity and triggered release of antimicrobials such as novel antimicrobial peptides.
  • Subsequently, you will assess the efficacy of the novel triggered release systems in these models against multi-drug resistant bacteria.
  • Since antimicrobial efficacy is also critically dependent on the host immune response, you will perform detailed studies on cellular immune responses, inflammatory mediators such as cytokines and their regulation.
  • You will perform part of the research during secondments at Koc University in Istanbul, Turkey, and at Paul Hartmann AG, Heidenheim, Germany.

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