PhD position

Updated: about 1 month ago
Deadline: 17 Jun 2024

4 Jun 2024
Job Information
Organisation/Company

University Medical Centre Groningen (UMCG)
Research Field

Medical sciences
Researcher Profile

Recognised Researcher (R2)
First Stage Researcher (R1)
Country

Netherlands
Application Deadline

17 Jun 2024 - 22:00 (UTC)
Type of Contract

Temporary
Job Status

Not Applicable
Hours Per Week

36.0
Is the job funded through the EU Research Framework Programme?

Not funded by an EU programme
Is the Job related to staff position within a Research Infrastructure?

No

Offer Description

The department of Rheumatology and Clinical Immunology at the UMCG, in close collaboration with Nephrology and Pathology & Medical Biology as the "Vasculitis Expertise Center Groningen," is looking for a PhD student. In this position, you will conduct research in the area of ANCA-associated vasculitides (AAV), focusing on the role of regulatory T cells (Tregs) in disease progression and treatment response. Are you the motivated and enthusiastic candidate with a background in immunology or related fields we are looking for? We would like to get to know you!
The project is a continuation of ongoing research into the dysregulation of immune tolerance in AAV, particularly concerning the role of Tregs. AAV are rare, chronic, relapsing autoimmune diseases characterized by inflammation of small blood vessels, commonly affecting the kidneys, lungs, and upper airways. Dysregulation of immune tolerance and the presence of anti-neutrophil cytoplasmic autoantibodies (ANCA) contribute to tissue damage in AAV. While immunosuppressive therapies have improved outcomes, AAV remains a chronic and relapsing condition. Identifying patients at risk of relapse poses a significant challenge.
We have previously reported that in AAV, the regulation of immunity by Tregs is disturbed. Whether this can be attributed to numerical differences, impaired function, or both is still under debate. In this translational project, we will use advanced techniques, like deep phenotyping and transcriptomic analysis, to explore phenotypic signatures that reflect intrinsic changes in Treg features in AAV. The overarching objective of this project is to identify distinct Treg characteristics in AAV patients that can serve as warning signs to identify individuals at risk of relapse and facilitate the monitoring of disease progression and treatment response. The project is sponsored by the Dutch Society of Rheumatology (ReumaNederland).
As a PhD student in this project, you will employ advanced techniques such as multiparameter spectral flow cytometry and (single cell) RNA sequencing to perform an in-depth assessment of phenotypic features, transcriptomic signatures, and functional characteristics of Treg subsets. You will investigate their association with disease status and treatment response in patients with AAV.
If you are passionate about immunology and eager to contribute to advancements in the treatment and understanding of autoimmune diseases, we encourage you to apply for this exciting opportunity.


Requirements
Specific Requirements

We are seeking a highly motivated candidate with a strong affinity for both the experimental and theoretical aspects of immunological research. The ideal candidate will possess sound immunological knowledge and demonstrate excellent communication skills, fluency in English (both written and spoken), and the ability to work independently as well as part of a team.
The successful candidate should hold a Master's degree in biological sciences or a related field. Experience with cell sorting/culture, multiparameter flow cytometry staining/analysis, and data analysis in R are highly desirable.
The UMCG has a preventive Hepatitis B policy. The UMCG can provide you with the vaccination, should it be required for your position.
In case of specific professions a ‘Certificate of Good Conduct’ is required.


Additional Information
Benefits

This position concerns a temporary position for 4 years on a fulltime basis (36 hours/week) with a formal evaluation after one year. The salary ranges from a minimum of € 3.017 ,- gross per month in the first year to a maximum of € 3.824 ,- gross per month in the final year, based on a full-time appointment. The conditions of employment comply with the CAO Universitair Medische Centra (CAO-UMC)


Selection process

dr. Wayel Abdulahad, [email protected] , telefoonnummer: 050 361 9270


Additional comments

dr. Wayel Abdulahad
050 361 9270
[email protected]


Website for additional job details

https://www.academictransfer.com/342218/

Work Location(s)
Number of offers available
1
Company/Institute
University Medical Center Groningen (UMCG)
Country
Netherlands
City
Groningen
Postal Code
9713 GZ
Street
Hanzeplein 1
Geofield


Where to apply
Website

https://www.academictransfer.com/en/342218/phd-position/apply/#apply

Contact
City

Groningen
Website

http://www.werken.umcg.nl/
Street

Hanzeplein 1
Postal Code

9713 GZ

STATUS: EXPIRED

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