PhD position: Surfaces for biosensing with single-molecule resolution

Updated: about 2 months ago
Deadline: 31 Aug 2017

We are looking for enthusiastic candidates.


Department of Applied Physics

Reference number


Job description

The group Molecular Biosensing for Medical Diagnostics (MBx, see ) at Eindhoven University of Technology (TU/e) creates ideas and generates scientific insights in the area of molecular biosensing with single-molecule resolution. This involves the engineering of molecular constructs for sensing applications (using protein, nucleic-acid, and protein-DNA technologies), methods to biofunctionalize nanoparticles, the development of novel single-molecule measurement methods, optical microscopies, particle characterization techniques, plasmonic effects, particle actuation principles, signal processing, and simulations. The research leads to novel methods for molecular biosensing, insights into protein function within complex and crowded environments, and novel routes into point-of-care and patient monitoring applications. The MBx group initiated and organizes the international competition on Sensors for Health ( ). Laboratories are shared with the Chemical Biology research group ( ) and the Institute for Complex Molecular Systems ( ).

PhD project

The PhD position is part of a collaboration between TU/e, Wageningen University and Research Centre (WUR), and six companies: Philips, Future Diagnostics, HyTest, Scienion, Stratec, and Synaffix. The PhD project at TU/e focuses on the development, characterization and understanding of surfaces for biosensing with single-molecule resolution. We propose a ‘Molecular Gecko’ approach, wherein antibodies with precisely defined linker polypeptides (provided by WUR) are attached to otherwise anti-fouling polymer-coated sensor surfaces. This new technology will be investigated and later demonstrated in experiments with medically-relevant biomarkers.

Job requirements

We are looking for enthusiastic candidates who are in an MSc program or who already have an MSc degree, preferably in Chemistry, Physics, Biomedical Engineering, or Nanotechnology. An interest in Physical Chemistry or Biophysics is required. Experience in advanced microscopies or single-molecule methods is a plus.

Conditions of employment

We offer:

  • A challenging job at a dynamic and ambitious University and in an enthusiastic team.
  • An appointment (1 fte) as a PhD-student for four years, starting date: as soon as possible.
  • Gross monthly salaries are in accordance with the Collective Labour Agreement of the Dutch Universities (CAO NU), increasing from
    € 2191 per month initially, to € 2801 in the fourth year.
  • An attractive package of fringe benefits, including excellent work facilities, end of the year allowance and sports facilities.

Information and application

More information can be obtained from Prof. M.W.J. Prins, Molecular Biosensing for Medical Diagnostics, Dept. of Applied Physics and Dept. of Biomedical Engineering, Eindhoven University of Technology. Phone +31 40 274 4018, .

If you are interested in this position, please send your application by using the 'Apply now'- button on this page. Your application must contain the following documents (in PDF format): letter of motivation, curriculum vitae, transcripts of BSc and MSc degrees (with courses and grades), copy of BSc and MSc theses, and contact information of two references.

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