PhD position: Structural Biology of the Neuronal Synapse

Updated: 4 months ago
Deadline: 15 Jun 2023

13 May 2023
Job Information

Delft University of Technology (TU Delft)
Research Field

Researcher Profile

First Stage Researcher (R1)

Application Deadline

15 Jun 2023 - 21:59 (UTC)
Type of Contract

Job Status

Not Applicable
Is the job funded through the EU Research Framework Programme?

Not funded by an EU programme
Is the Job related to staff position within a Research Infrastructure?


Offer Description

A 4-year position is available for a PhD candidate in the research group of Dimphna Meijer, Department of Bionanoscience, Delft University of Technology, the Netherlands.

The long-term goal of our research is to understand synapse assembly and disassembly at the molecular level, during health and disease. We address questions such as: What is the underlying structural basis of synapse formation? What happens at the nanoscale in a diseased brain? We have recently determined several cryo-EM structures of synaptic cell adhesion molecules that together reveal part of a molecular recognition code. We are now aiming to understand molecular recognition and synapse formation in a cellular context using a combination of protein biochemistry & biophysics, structural biology, and mammalian cell biology approaches.

The successful applicant will be the driver of a new project concerning detailed structural characterization of synapse assembly with a bottom-up approach. State-of-the-art equipment, including high-end light and (cryo-)electron microscopes, as well as advanced mammalian cell culture facilities are available in our department.

We are an international, growing team of multidisciplinary scientists. We aim for a high-impact, supportive environment, where talented people work together to solve neurobiological questions. See also our group website .

Specific Requirements

We are looking for a highly motivated and goal-oriented researcher that is willing to take on new challenges. The candidate has a M.Sc. degree in nanobiology, biochemistry/biophysics, structural biology, or related field. The ideal applicant has experience with single-molecule or structural biology approaches, and is interested in applying cryo-electron microscopy and cryo-electron tomography to neurobiological questions. Cryo-EM/Cryo-ET experience is a plus but not required. The candidate should be fluent in English and motivated to work in an ambitious and collaborative research team.

Additional Information

We offer an appointment as PhD student for a period of 1.5 year, which will be extended with a second term of 2.5 years if the candidate performs well. Remuneration will be according to the PhD scales set by the Collective Labour Agreement for Dutch Universities (CAO NU), and will range from € 2.541 per month in the first year to € 3.247 per month in the fourth year (gross amounts, in case of fulltime employment). Applicants should have the right to work in the Netherlands for the duration of the contract. Fulltime is considered to be 38 hours per week.

Selection process

Are you interested in this vacancy? Please apply before 15 June 2023 via the application button and upload the following information in English (pdf format only):

  • Letter of motivation (generic letters will be disregarded).
  • Detailed CV.
  • Three names of potential references.

  • Additional comments

    For more information about this vacancy, please contact Dr. Dimphna Meijer, Principal Investigator, e-mail:

    Website for additional job details

    Work Location(s)
    Number of offers available
    Delft University of Technology
    Postal Code
    2628 CD
    Mekelweg 2

    Where to apply



    Mekelweg 2
    Postal Code

    2628 CD

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