Understanding the structure, aggregation, and folding of proteins is a major research area nowadays. Improper folding and aggregation of specific proteins are among the common cause of neurodegenerative disorders such as Alzheimer’s and Parkinson’s disease. These diseases currently have a growing prevalence in the world and a high societal economic cost. While protein aggregation has been widely studied, there exists a manifold of questions about the evolution of structural conformations of single proteins before and during aggregation, the aggregation rates of single protein molecules binding to a fibril, and the forces and mechanisms that influence aggregation at the single-molecule level. Insight into these mechanisms can have a great implication for neurodegenerative diseases.
The aim of this project is to realise novel nanophotonic structures that confine optical fields in a deep subwavelength space to probe the structure of single protein molecules. Localized plasmons from plasmonic nanocavities can enhance optical intensity by several orders of magnitude and this will be used to amplify the weak intensity from single proteins. This project will explore new approaches to efficiently interface nano-optical light confinement with protein molecules without influencing their aggregation rates or structures. We are interested to study alpha-synuclein protein, which is the main cause of Parkinson’s disease and it contributes to other neurogenerative diseases. You will work with a team that has expertise in biophysics, single molecule spectroscopy, and nanophotonics.
Ph D Student: Ubiquitin Mediated Protein Processing At The Single Molecule Level, Using Optical Tweezers And Fluorescence, AMOLF, Netherlands, about 2 hours ago
Protein chains undergo dramatic changes during their lifetime, beyond their initial folding. Eukaryotic cells possess an intricate ubiquitin protein ‘labelling’ system to regulate these changes. T...
Doctoral Candidate Plant And Single Cell Protein Processing , ETH Zurich, Switzerland, about 16 hours ago
In der aktuellen Covid-19 Situation laufen die Rekrutierungen weiter. Es kann dabei allerdings zu Verzögerungen kommen. Vielen Dank für Ihr Verständnis. 100%, Zurich, fixed-term The Sustainable Fo...
Ph D Student Position In Chemical Protein Synthesis , University of Zurich, Switzerland, about 5 hours ago
Department of Chemistry PhD student position in chemical protein synthesis 60 % A PhD student position is available in the group of Prof. Dr. Nina Hartrampf in the Department of Chemistry at Univer...
Ph D Position In The Project “Amyloids In Alzheimer’s Disease And Protein Based Biomaterials”, Karolinska Institutet, Sweden, about 24 hours ago
The Department of Biosciences and Nutrition performs research and education in several areas of medical science including aging, Alzheimer, biomaterial, molecular endocrinology, cancer biology, fu...
Ph D Position At The Vorobieva Lab, VIB, Belgium, about 11 hours ago
Ph.D. position – High-throughput in silico design and experimental characterization of membrane proteins About the Lab The laboratory of computational protein design, headed by Dr. Anastassia Voro...
Postdoctoral Position In Directed Evolution , ETH Zurich, Switzerland, about 16 hours ago
In der aktuellen Covid-19 Situation laufen die Rekrutierungen weiter. Es kann dabei allerdings zu Verzögerungen kommen. Vielen Dank für Ihr Verständnis. 100%, Zurich, fixed-term The recently forme...