Cell division is an extremely dynamic process, and errors in this phase of the cell cycle have far-reaching consequences. Studying the protein dynamics at relevant scale is not trivial, as the dynamical interplay is at scales much smaller than the diffraction limit of light, and thus beyond the reach of traditional microscopes. Stimulated Emission Depletion (STED) microscopy on the other hand does allow imaging with a resolution of 30 nanometres even in living cells.
In this PhD research project, you will have the following main responsibilities and tasks:
- develop hardware and software solutions to study protein structures during cell division
- develop software solutions for data analysis routines for STED nanoscopy
- prepare, measure and analyse samples using life cell STED nanoscopy.
The work will be diverse, as it will besides the optics and software developments, also include among others (life cell) sample preparation and data analysis.
You will work in an international and interdisciplinary research environment closely together both with colleagues of the Molecular Biophysics group at the Zernike Institute, as well as with several labs in the Groningen Biomolecular Sciences and Biotechnology Institute (GBB) and several international collaborators.
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