PhD position in neuroscience to study epilepsy and neuromodulation using optical techniques

15 Feb 2024
Job Information

Organisation/Company

Erasmus MC (University Medical Center Rotterdam)

Research Field

Medical sciences

Researcher Profile

Recognised Researcher (R2)
First Stage Researcher (R1)

Country

Netherlands

Application Deadline

26 Feb 2024 - 23:00 (UTC)

Type of Contract

Temporary

Job Status

Not Applicable

Hours Per Week

36.0

Is the job funded through the EU Research Framework Programme?

Not funded by an EU programme

Is the Job related to staff position within a Research Infrastructure?

No

Offer Description

Project description:
Epilepsy is a debilitating condition marked by excessive and synchronized neural seizure activity, resulting in a range of cognitive and behavioral symptoms. Deep Brain Stimulation (DBS) stands out as a promising neuromodulation technique, involving the electrical stimulation of deep brain circuits. This approach has shown efficacy in suppressing seizures, even in cases of medication-resistant epilepsy, and improving overall clinical symptoms. Nevertheless, our understanding of the cellular-level mechanisms through which DBS operates remains limited. Here, using high-speed voltage fluorescence microscopy and electrophysiology techniques, you will delve into the microcircuit mechanisms underlying epilepsy and DBS. You will use recently developed genetically encoded voltage indicators to record single-cell membrane voltage signals during DBS to understand how neural circuits are modulated by DBS and how these changes are suppressing seizures. The ultimate goal is to enhance our comprehension of the biophysical mechanisms underlying DBS and, in turn, develop more targeted approaches for employing DBS in the treatment of epilepsy.This project is funded by ERC starter grant `OptoDBS'.

If you find this interesting, please apply!

Responsibilities:

• Design and execute fluorescence imaging experiments.
• Analyze and interpret collected data.
• Write scientific papers.
• Report results at conferences.

Requirements
Specific Requirements

• You have successfully obtained a MSc degree (or will shortly graduate), in the field of Neuroscience, Life Science, Biophysics or related field.
• Experience in optical imaging/manipulation and/or electrophysiology is a plus
• Proficiency in widely used programming languages (Python, Matlab) or the willingness to learn a programming language is a condition for the appointment.
• You are preferably available in late summer 2024 (the latest per September 1st, 2024).

Additional Information
Benefits

• You will receive a temporary position for 3 years.
• The gross monthly salary is € 2.901,- in the 1st year and gradually increases to € 3.514,- in the 3th year (scale OIO).
• Excellent fringe benefits, such as a 13th month that is already paid out in November and a individual travel expense package.
• Working from home is optional.
• An International Office which aids you in preparing for you arrival and stay.
• Pension insurance with ABP. We take care of approximately 2/3 of the monthly contribution.
• Special benefits, such as a incompany physiotherapist and bicycle repairer. And there is also a gym where you can work on your fitness after work.

Selection process

For more information about this position, please contact dr. Eric Lowet, assistent professor via [email protected] . If you are excited by the thought of this position and would like to apply, please do so by using the application form on our website.

Additional comments

For more information about this position, please contact dr. Eric Lowet, assistent professor via [email protected] . If you are excited by the thought of this position and would like to apply, please do so by using the application form on our website.

Website for additional job details

https://www.academictransfer.com/337776/

Work Location(s)

Number of offers available

1

Company/Institute

Erasmus MC

Country

Netherlands

City

Rotterdam

Postal Code

3015 GD

Street

Dr. Molewaterplein 40

Where to apply

Website

https://www.academictransfer.com/en/337776/phd-position-in-neuroscience-to-stud…

Contact

City

Rotterdam

Website

http://www.erasmusmc.nl/

Street

Dr. Molewaterplein 40

Postal Code

3015 GD

STATUS: EXPIRED