Applications are invited for a 4-year PhD study, starting as soon as possible, in the research group of Prof. Matthias Heinemann, (https://www.heinemannlab.eu) at the Groningen Biomolecular Sciences and Biotechnology Institute. Please see the position as a postdoc in Dynamic single-cell analysis also: https://www.rug.nl/about-ug/work-with-us/job-opportunities/?details=00347-02S000985P
The eukaryotic cell cycle is a fascinating research topic. While we know many of the cell biological changes and biochemical control mechanisms, it turns out that there is still so much that we do not understand. For instance, we just recently showed that also metabolism is dynamic during the cell cycle, and a metabolic oscillator might even exert cell cycle control (Papagiannakis et al, 2017, Molecular Cell; Litsios et al, 2019, Nature Cell Biology).
The aspect that we now want to explore within this project is the following: We have recently obtained indication that the rate of protein synthesis is dynamic during the cell cycle, meaning that the ribosome produces different amounts of protein at different moments. Using budding yeast as a model, we now want to unravel the molecular mechanisms that tune the activity of the ribosome as a function of the cell cycle progression.
To this end, we will use highly sophisticated quantitative microscopic analyses with microfluidics as well as different dynamic state-of-the-art perturbation methods, such as the auxin-dependent protein depletion system and optogenetics. Using CRISPR-based genetic engineering, we will also construct different reporter strains that allow us to monitor the effect of the introduced dynamic perturbations.
Ph D Position In Quantitative Cell Biology/Biochemistry (1.0 Fte), University of Groningen, Netherlands, about 2 hours ago
We are looking for a highly motivated and enthusiastic PhD candidate with a strong background in (bio)chemistry, cell biology, (bio)physics or closely related fields to join the Cell Cycle Dynamic...
Ph D Position In Quantitative Cell Biology/Biochemistry (1.0 Fte), University of Groningen, Netherlands, about 18 hours ago
Organisation Founded in 1614, the University of Groningen enjoys an international reputation as a dynamic and innovative centre of higher education offering high-quality teaching and research. Fle...
Ph D Position: Bottom Up Reconstruction Of A Self Dividing Artificial Cell Using Microfluidics, Katholieke Universiteit Leuven, Belgium, 1 day ago
What distinguishes a living organism from a simple mixture of chemical reactions? It is generally agreed that a living organism needs to satisfy a basic set of conditions: compartmentalize its com...
Ph D Position In Quantitative Cell Biology/Biochemistry (1.0 Fte), University of Groningen, Netherlands, about 8 hours ago
PhD position in Quantitative Cell Biology/Biochemistry (1.0 FTE) (222433) « Back to the overview Job description We are looking for a highly motivated and enthusiastic PhD candidate with a strong ...
Ph D Student B Cell Differentiation, Sanquin Blood Supply Foundation (Sanquin), Netherlands, 6 days ago
The program investigates regulation of antibody responses to be able to prevent occurrence of unwanted antibody responses against red blood cells (RBCs), platelets or other blood products. The pos...
Ph D Student Position, University of Gdansk, Poland, 3 days ago
Requirements: - MSc degree in molecular biology, biotechnology, biology or related discipline - Experience on cell cultures (experience in cell manipulation and transfection techniques would be a ...