PhD Position in Computational Toxicology (1.0 FTE)

Utrecht University, Netherlands

Updated: over 2 years ago
Job Type: Temporary
Deadline: 16 Nov 2021

The Veterinary and Comparative Pharmacology Group of the Institute of Risk Assessment Sciences at Utrecht University is looking for a PhD candidate to contribute to the development of computational approaches to the toxicological risk assessment of cardiotoxic chemicals.
As our PhD candidate you will develop physiologically-based kinetic (PBK) models and other computational approaches to analyze, synthesize and extrapolate toxicokinetic and toxicodynamic data generated by new approach methodologies (NAMs) for chemical risk assessment. You will be part of an international multi-disciplinary team that uses innovative in vitro, -omics and computational approaches to study the effects of chemicals on cardiac tissue. One of your tasks will be to perform a systematic review and integrate toxicological evidence from the literature to identify chemical compounds, associated with adverse cardiovascular health outcomes. Your focus will be to develop mechanistic, biologically based models that predict chemical concentrations at target sites in the body (reverse dosimetry), and in such a manner that in silico and in vivo data can be extrapolated to in vivo exposure scenarios and case studies.


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