PhD position in biophysics: Cell division at the nanoscale (1.0 FTE)

PhD position in biophysics: Cell division at the nanoscale (1.0 FTE) (222491)

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Job description

We are looking for a PhD candidate with a biophysics background. The aim of this PhD project is to develop (live-cell) STED super resolution microscopy methods to visualize how the DNA copies are separated during cell division. Affinity for wet-lab work, and experience in general programming (Python) and optics are desirable.

You will have the following main responsibilities and tasks:

• develop protocols for optimal labelling of cell-division proteins for STED and expansion microscopy
• develop image analysis algorithms using Python
• investigate minimal impact imaging protocols.

We are studying how protein structures change during cell division with STED microscopy. Cell division is a very dynamic process, and errors in this phase of the cell cycle have far-reaching consequences. Visualizing the protein dynamics at relevant scales is not trivial, as the dynamical interplay is at scales much smaller than the diffraction limit of light, and thus beyond the reach of traditional microscopes. STED microscopy however does allow imaging with a resolution of 30-40 nanometres even in living cells. In fixed cells, the combination with STED and expansion microscopy even reaches better resolutions. To successfully study this dynamic process is challenging.

With your biophysics background, and affinity for programming and wet-lab work, you are the ideal fit to lift our research to another level! The work will be diverse, including (live-cell) sample preparation, protocol optimization, measurements and software development for data analysis.

You will work in an interdisciplinary and international research environment with local colleagues and international collaborators from physics, biomolecular sciences, and informatics.

Qualifications

You have/are:

• a European Master’s degree (or equivalent) in physics, biophysics, nanoscience or biomedical engineering
• an excellent track record
• highly motivated and able to work in a multidisciplinary and international work environment
• excellent communication skills in both oral and written English
• experience in programming (e.g. python, …).
Experience in (cell)biology is highly appreciated but not required.

Organisation

Since its foundation in 1614, the University of Groningen has established an international reputation as a dynamic and innovative university offering high-quality teaching and research. With its 36,000 students and Nobel prize winning researchers, University of Groningen ranks among the top universities globally. It is situated in the vibrant capital of the northern Netherlands, Groningen.

We offer this position in the stimulating, diverse, international research environment of the Zernike Institute for Advanced Materials. A world-class academic institute with a multi-disciplinary research programme that encourages close collaborations between theoretical and experimental groups with different expertise.

Conditions of employment

We offer you following the Collective Labour Agreement for Dutch Universities:

• a salary of € 2,541 gross per month in the first year, up to a maximum of € 3,247 gross per month in the fourth and final year
• a holiday allowance of 8% of gross annual income and an 8.3% end-of-the-year allowance
• a minimum of 29 holidays and additional 12 holidays in case of full-time employment
• a full-time position (1.0 FTE).

The successful candidate will first be offered a temporary position of one year with the option of renewal for another three years. Prolongation of the contract is contingent on sufficient progress in the first year to indicate that successful completion of the PhD thesis within the next three years is to be expected. A PhD training program is part of the agreement and the successful candidate will be enrolled in the Graduate School of Science and Engineering.

The preferred starting date is as soon as possible

Application

Do you meet our qualification criteria? If yes, please write a motivation letter in which you clarify how you match with this PhD position, what attracts you in the work and/or what you envision to achieve.

Your application thus should include:

• cv
• motivational letter.

You can submit your application until 28 August 23:59 pm / before 29 August 2022 Dutch local time (CET) by means of the application form (click on "Apply" below on the advertisement on the university website).

The University of Groningen strives to be a university in which students and staff are respected and feel at home, regardless of differences in background, experiences, perspectives, and identities. We believe that working on our core values of inclusion and equality are a joint responsibility and we are constructively working on creating a socially safe environment. Diversity among students and staff members enriches academic debate and contributes to the quality of our teaching and research. We therefore invite applicants from underrepresented groups in particular to apply. For more information, see also our diversity policy webpage: https://www.rug.nl/(...)rsity-and-inclusion/

Our selection procedure follows the guidelines of the Recruitment code (NVP): https://www.nvp-hrnetwerk.nl/sollicitatiecode/ and European Commission's European Code of Conduct for recruitment of researchers: https://euraxess.ec.europa.eu/jobs/charter/code

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.

Unsolicited marketing is not appreciated.

Information

For information you can contact:

• Rifka Vlijm, Assistant Professor, [email protected]

Please do not use the e-mail address(es) above for applications.

Apply