PhD position in Biofabrication and Bioprinting for Regenerative Medicine

9 May 2024
Job Information

Organisation/Company

University Medical Center Utrecht (UMC Utrecht)

Research Field

Medical sciences

Researcher Profile

First Stage Researcher (R1)

Country

Netherlands

Application Deadline

15 Jun 2024 - 21:59 (UTC)

Type of Contract

Temporary

Job Status

Not Applicable

Hours Per Week

36.0

Is the job funded through the EU Research Framework Programme?

Not funded by an EU programme

Is the Job related to staff position within a Research Infrastructure?

No

Offer Description

Hematopoietic stem cell (HSC) production is a vital process for maintaining a healthy blood system and enabling life-saving treatments like HSC transplantations. Producing HSCs in the laboratory would revolutionize medical treatments by providing transplantation options for nearly all patients in need. Yet, much remains to be learned about the generation and growth of HSCs. Research in this area has faced significant challenges due to limitations in studying the native birthplace of HSCs within embryos in the aorta, and the absence of suitable laboratory models. To overcome these obstacles, we are pioneering an innovative volumetric 3-dimensional bioprinting technology (ultra-fast bioprinting developed in our lab), crafting miniature artificial replicas of the embryonic aorta. We will use our bioprinted tissue to explore how blood flow and haemodynamics, environmental biomechanical and biochemical signals, and various local geometrical changes influence HSC production. Our work will form the foundation for groundbreaking discoveries and will ultimately aid to produce HSCs in our bioprinted and perfusable mini-factories.

This PhD position is part of the multidisciplinary ZonMw Open Competition funded project entitled “b3D-AGM, a bioengineered cradle to produce bona fide hematopoietic stem cells in vitro.

Your challenge within this project is to develop a volumetric 3D bioprinting strategy to replicate the mechanical and chemical environment of the embryonic aorta, simulate different hemodynamic flow profiles in computational and experimental set-ups, and to develop dynamic perfusion and culture regimes, needed for tissue engineering and HSC generation.

Requirements
Specific Requirements

• You hold a Master’s degree in biomedical engineering, biophysics, bioengineering, materials science, mechanical engineering or related disciplines.
• Strong interest to collaborate with consortium partners with background in developmental biology.
• Expertise in 3D bioprinting, additive manufacturing and biomaterials.
• Expertise in fluid dynamic simulation and finite element analysis will be positively evaluated.
• Expertise in cell culture and tissue engineering will be positively evaluated.
• Ability to work in a multidisciplinary research environment and to contribute to team efforts and projects.
• Ability to communicate effectively scientific ideas, foster collaboration and independent thinking.
• Proven proficiency in written and spoken English.

Additional Information
Benefits

The maximum salary for this position (36 - 36 hours) is € 3.824,00 gross per month based on full-time employment.

In addition, we offer an annual benefit of 8.3%, holiday allowance, travel expenses and career opportunities. The terms of employment are in accordance with the Cao University Medical Centers (UMC).

Additional comments

Contact our colleague:
dr. Riccardo Levato
088 75 555 55
[email protected]

Website for additional job details

https://www.academictransfer.com/341415/

Work Location(s)

Number of offers available

1

Company/Institute

UMC Utrecht

Country

Netherlands

City

Utrecht

Postal Code

3584CX

Street

Heidelberglaan 100

Geofield

Where to apply

Website

https://www.academictransfer.com/en/341415/phd-position-in-biofabrication-and-b…

Contact

City

Utrecht

Website

http://www.umcutrecht.nl/

Street

Heidelberglaan 100

Postal Code

3584 CX

STATUS: EXPIRED