We are looking for a highly motivated and enthusiastic PhD student with strong backgrounds in chemistry, biochemistry, biotechnology or closely related fields to join the research group of Dr Sandy Schmidt, (http://schmidt-researchgroup.com
) at the Department of Chemical and Pharmaceutical Biology (https://www.rug.nl/research/grip/cpb/
) within the Groningen Research Institute of Pharmacy (GRIP). The position is funded for four years by the recently awarded ERC Starting grant ‘ReCNNSTRCT’.
Biocatalysis uses enzymes to replace traditional catalysts. This technology has already established sustainable enzymatic approaches across various industrial sectors and led to economic and environmental benefits. Despite the growing impact of biocatalysis in industrial chemistry, the full potential of this technology is yet to be unlocked. Important current limitations are the following: i) only a limited set of chemical reactions is amenable to biocatalysis; and ii) the unique enzymology encoded in the genome of organisms is yet only minimally explored.
In this context, we are interested in decoding novel reaction chemistries from the underexploited family of N-N bond-forming enzymes (NNZYMES), while tackling reactions that are difficult to realize by traditional chemical approaches and currently not feasible by enzyme catalysis. With this, we intend to build important molecules such as precursors for pharmaceuticals. A particular focus thereby lies on enzymes from natural product biosynthetic gene clusters that catalyze unique chemical reactions, but are tremendously underexplored as sustainable biocatalysts in the chemical industry. Although their native reactions have recently been investigated, the lack of knowledge on how these enzymes perform challenging reactions hinders a systematical exploration of their reactivity toward non-natural substrates and transformations.
To fill this knowledge gap, in this PhD project we will extend the toolbox of NNZYMES as novel biocatalysts to access various N-N bond-containing compounds. In the laboratory, we thereby combine bioinformatic analysis with enzyme biochemistry, instrumental analysis, protein engineering and (bio)catalysis to elucidate diverse N-N bond-forming reaction chemistries.
The research group of Dr. Schmidt is embedded in the Chemical and Pharmaceutical Biology unit at the GroningenResearch Institute of Pharmacy, which provides an inspiring, interdisciplinary and collaborative research environment.
Founded in 1614, the University of Groningen enjoys an international reputation as a dynamic and innovative center of higher education offering high-quality teaching and research. Flexible study programmes and academic career opportunities in a wide variety of disciplines encourage the 36,000 students and researchers alike to develop their own individual talents. As one of the best research universities in Europe, the University of Groningen has joined forces with other top universities and networks worldwide to become a truly global center of knowledge. The Faculty of Science and Engineering (FSE) is the largest faculty within the University. We offer first-rate education and research in a wide range of science and engineering disciplines. Our community has an open and informal character with students and staff from around the world.
The research group Chemical and Pharmaceutical Biology (CPB) within GRIP consists of an enthusiastic group of researchers from different parts of the world. The scientific staff currently includes two full professors, one associate professor, and two assistant professors. In addition, two postdocs, four technicians and >25 PhD students are members of the research group. A strong research focus of CPB is on the creation of superior biocatalysts for the sustainable production of pharmaceuticals.
The ideal candidate for this project is an experimental chemist, with affinity or interest in biocatalysis, bioinformatics and protein engineering.
Your profile includes:
- a Master degree in chemistry, biotechnology, biochemistry or related field
- ability to work in an international team
- inter- and multidisciplinary thinking
- high motivation
- an integrative and cooperative personality with excellent communication and social skills
- fluency in English – written and oral.
We offer you, in accordance with the Collective Labour Agreement for Dutch Universities:
- a salary of € 2,541 gross per month in the first year, up to a maximum of € 3,247 gross per month in the fourth and final year
- a holiday allowance of 8% gross annual income
- an 8.3% end-of-year bonus and participation in a pension scheme for employees
- first, a temporary position of one year with the option of renewal for another three years. Prolongation of the contract is contingent on sufficient progress in the first year to indicate that a successful completion of the PhD thesis within the next three years is to be expected. A PhD training programme is part of the agreement and the successful candidate will be enrolled in the Graduate School of Science and Engineering.
The ideal starting date is May-June 2023, however, there is considerable flexibility in the starting date.
The conditions of employment: https://www.rug.nl/about-us/work-with-us/
Ph D Student: Chiral, AMOLF, Netherlands, about 13 hours ago
The Self-Organizing Matter group seeks motivated and talented PhD students to join our team working in the field of chirality. We are fascinated by how simple physical chemical phenomena can lead ...
Ph D Position In Biophysical Chemistry, Uppsala University, Sweden, 1 day ago
Published: 2023-03-31 Uppsala University is a comprehensive research-intensive university with a strong international standing. Our ultimate goal is to conduct education and research of the highe...
Ph D/Postdoc Position In Cloud Aerosol Interaction (1.0 Fte) , Utrecht University, Netherlands, about 11 hours ago
Print this page PhD/Postdoc position in Cloud-Aerosol interaction (1.0 FTE) Job description For the CAINA (cloud-aerosol reactions in a nitrogen dominated atmosphere) project we are looking for a...
Ph D Position On Crispr Diagnostics On Chip For Early Cancer Detection, University of Twente, Netherlands, about 19 hours ago
Vacancies PhD position on CRISPR diagnostics on-chip for early cancer detection Key takeaways Previously, we have presented an in vitro diagnostic tool for methylation quantification and identifi...
Ph D Student In Computer Aided Drug Design (Msca Cofund Project Prismas), Uppsala University, Sweden, 1 day ago
Published: 2023-03-03 Uppsala University is a comprehensive research-intensive university with a strong international standing. Our ultimate goal is to conduct education and research of the highe...
Ph D Student: Chiral, AMOLF, Netherlands, 18 days ago
PhD-student: Chiral PhD-student: Chiral Published Deadline Location yesterday 10 Sep Amsterdam Job description The Self-Organizing Matter group seeks motivated and talented PhD students to join ou...