PhD position - Flow Chemistry - University of Amsterdam

Updated: about 2 months ago
Job Type: FullTime
Deadline: 05 Sep 2020

Direct C–H activation has emerged as a promising new strategy to establish the coupling of two carbon fragments. The formation of such carbon-carbon bonds are of great importance for the development of pharmaceuticals and other biologically active molecules. While most of the current methods involve the use of liquid phase or soluble reagents, gaseous building blocks are often overlooked due to the apparent complexity of the required setup. The Noel Research Group aims to expand chemical space by selecting those starting materials which are often overlooked. To handle such challenging reaction conditions, our group uses flow technology which provides excellent mass and heat transfer allowing to accelerate many chemical reactions. As such, unique C–H activation protocols have been developed which allow the activation of volatile alkanes or the use of oxygen and volatile olefins as coupling partners.

References:

[1] Science 2020, 369 (6499), 92-96.

[2] Angewandte Chemie International Edition 2018, 57 (15), 4078-4082.

[3] Chemistry – A European Journal 2018, 24(53), 14079-14083.


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