Pathologie & Medische Biologie
Chronic obstructive pulmonary disease (COPD) is a prevalent inflammatory disease characterized by irreversible airflow obstruction as well as skeletal muscle wasting. The disease has high morbidity and mortality, and with more than 300 million deaths yearly, it is the 3rd leading cause of death worldwide. Disturbed damage and repair responses have been implicated in both lung and muscle pathology in COPD, resulting in airway disease, alveolar tissue destruction (emphysema) and skeletal muscle weakness. The tissue damage in COPD is severe and irreversible. Therefore, there is an urgent need to understand and target the mechanisms leading to impaired tissue regeneration in COPD. Emerging evidence implicates a role for mitochondrial impairment in lung and muscle pathology in COPD. Funded by a ZonMW-Open consortium grant, we will address this in our project.
Our project MITOREG aims to reveal the intricate interplay between MITOchondrial function and tissue REGeneration. We will investigate a novel concept on the crosstalk between lung and muscle. We will examine whether COPD-related mitochondrial dysfunction can be restored by stimulation of local and systemic mitochondrial rejuvenation in order to reinforce the regenerative capacity of muscle and lung.
Within the UMCG, the PhD student who will work on the lung epithelial cell culture studies, comparing mitochondrial function in primary epithelial cells from well-characterized COPD and control subjects and relating this to abnormal repair and regenerative responses, using advanced, patient-specific models including organoids and organ-on-chip. In addition, the PhD student will collaborate with the PhD student from Maastricht on lung-muscle interaction and potential interventions, using the organ-on-chip model set-up by a post-doc working in Verpoorte’s group.
Techniques to be used will be e.g. cell culture, using air-liquid interface and organoid models, electrical resistance measurements, mitochondrial respiration (Oroboros/Seahorse analyzer), qPCR, flow cytometry, ELISA, immunofluorescent staining, potentially mass spectrometry.
Ph D Position Molecular Pharmacology (1.0 Fte), University of Groningen, Netherlands, 9 days ago
The Groningen Research Institute of Pharmacy (GRIP) of the Faculty of Science and Engineering has a position for a PhD candidate in the department of molecular pharmacology. The project is funded ...
Ph D Position Molecular Pharmacology (1.0 Fte), University of Groningen, Netherlands, about 4 hours ago
Organisation Founded in 1614, the University of Groningen enjoys an international reputation as a dynamic and innovative institution of higher education offering high-quality teaching and research...
Ph D Student In Computational Systems Biology At Cic Bio Gune, Center for Cooperative Research in Biosciences (CIC bioGUNE), Spain, 11 days ago
The Computational Biology Group at CIC bioGUNE seeks a highly skilled and motivated PhD student to work on an exciting project that aims at developing a computational framework for modeling inter-...
Postdoc Fellowship: Measuring Skeletal Muscle Adaptation To Exercise For Applications In..., University of Twente (UT), Netherlands, 4 days ago
Are you passionate about investigating how human skeletal muscles change their biological structure in response to injury, training and robot-interaction? Are you interested in contributing to dev...
Engineering Post Doctoral Position To Advance Single Organoid Analysis , ETH Zurich, Switzerland, about 22 hours ago
In der aktuellen Covid-19 Situation laufen die Rekrutierungen weiter. Es kann dabei allerdings zu Verzögerungen kommen. Vielen Dank für Ihr Verständnis. 100%, Zurich, fixed-term This project is pa...
Postdoctoral Position At Center For Healthy Aging, The Department Of Cellular And Molecular..., University of Copenhagen (UCPH), Denmark, 6 days ago
A postdoctoral position is available at The Department of Cellular and Molecular Medicine (ICMM). The position is for 3 years with a start date of 1 January 2022, or upon agreement. Job descriptio...