PhD position: Cancer cell biology

Updated: about 2 months ago
Deadline: 29 Jun 2024

2 Jun 2024
Job Information

Utrecht University
Research Field

Medical sciences
Researcher Profile

Recognised Researcher (R2)
First Stage Researcher (R1)

Application Deadline

29 Jun 2024 - 21:59 (UTC)
Type of Contract

Job Status

Not Applicable
Hours Per Week

Is the job funded through the EU Research Framework Programme?

Not funded by an EU programme
Is the Job related to staff position within a Research Infrastructure?


Offer Description

Are you interested in fundamentally understanding the molecular mechanisms that allow cancer cells to persist despite therapy? Are you excited to become an expert in single cell analysis? Then this PhD position might be a great match for you!
We offer a PhD position in a project that is funded by the Dutch Cancer Foundation (KWF). This project is aimed at better understanding how some cancer cells manage to escape chemotherapy treatment, focusing on patients with metastatic ovarian cancer.
Your job
In this project, you will dissect heterogeneous tumor cell behavior using state-of-the-art imaging techniques, in vitro models, and patient biopsies. You will combine two experimental approaches to quantify cancer drug responses:

  • You will use mass cytometry imaging to measure how much of the chemotherapeutic drugs are reaching individual cancer cells, and how these cells are responding in ovarian cancer biopsies and in vitro models.
  • You will engineer cancer cell lines to express fluorescent reporters, and develop automated data analysis workflows to track heterogenous drug responses and cell cycle fates over time.

  • Requirements
    Specific Requirements

    You are interested in cell biology and have a learning and exploring attitude. You are keen to develop yourself personally and professionally. You put your good collaboration and communication skills to good use. Specifically, you:

    • have (or are close to completing) a Master’s degree in Biomedical Sciences, Molecular & Cellular Biology or a closely related field;
    • demonstrate experience with 2D/3D mammalian cell culturing and with molecular cloning;
    • have experience with image analysis (preferably cell segmentation and cell tracking).

    Additional Information

    We offer

    • a position for four years in an international working environment.
    • a working week of 36 hours and a gross monthly salary ranging from €2,770 in the first year to €3,539 in the fourth year in the case of full-time employment (salary scale P under the Collective Labour Agreement for Dutch Universities (CAO NU);
    • 8% holiday pay and 8.3% year-end bonus;
    • a pension scheme, partially paid parental leave and flexible terms of employment based on the CAO NU.

    In addition to the employment conditions from the CAO for Dutch Universities, Utrecht University has a number of its own arrangements. These include agreements on professional development , leave arrangements, sports and cultural schemes and you get discounts on software and other IT products. We also give you the opportunity to expand your terms of employment through the Employment Conditions Selection Model. This is how we encourage you to grow. For more information, please visit working at Utrecht University .

    Selection process

    As Utrecht University, we want to be a home for everyone. We value staff with diverse backgrounds, perspectives and identities, including cultural, religious or ethnic background, gender, sexual orientation, disability or age. We strive to create a safe and inclusive environment in which everyone can flourish and contribute.
    To apply, please send your curriculum vitae, including a letter of motivation, via the ‘apply now’ button.

    Additional comments

    This project is supervised by Dr. Bart Westendorp . If you have any questions regarding this vacancy, please contact [email protected] , or phone +31 6 39 585 526.

    Website for additional job details

    Work Location(s)
    Number of offers available
    Universiteit Utrecht
    Postal Code
    Heidelberglaan 8

    Where to apply



    Domplein 29
    Postal Code

    3512 JE


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