Inbedding
Dit project is onderdeel van het Consortium programma TRACER ( treating hereditary anemias through stem cell research) binnen het door ZonMW gefinancierde translationele onderzoeksprogramma ‘Pluripotent Stem cells for Inherited Diseases and Embryonic Research’ (PSIDER). Hieronder een korte samenvatting van het Tracer programma (in het Engels):The production or function of blood cells is impaired in a plethora of diseases presenting early in life such as congenital anemias that persist over lifetime. Blood transfusion is often the only therapeutic option, and stem cell transplantation the only curative treatment for severe anemias. Unfortunately, a lack of immune-matched cells often hampers these therapies. The multidisciplinary TRACER team aims to employ iPSCs to: 1) study disease mechanisms, 2) generate engraftable hematopoietic stem cells (HSCs), and 3) develop curative therapies. The TRACER project focuses on two different hereditary anemias: Sickle Cell Diseaseand Diamond Blackfan Anemia. We will focus on mechanisms involved in these hereditary anemias, and on the production of mature blood cells and HSCs from gene-corrected iPSCs. Such an advanced stem cell technology project requires in-depth study of the ethical, legal and societal impact of these new technologies on patients, clinicians, policymakers, regulatory bodies, pharmaceutical enterprises and the general public, to ensure that the benefits will reach the patients.
Tasks
As a PhD candidate on this multidisciplinary scientific project, your tasks are to:
- Conduct a literature review and automated text analysis of traditional and social media articles and posts about iPSCs for biobanking, research, and as gene-edited products for stem cell transplantation of patients.
- Conduct focus groups and obtain expert opinions of different stakeholder groups in the Netherlands on the use, culturing, processing and editing of iPSCs for their personal lives or respective work fields.
- Administer a survey and vignette study of different scenarios about development and application of iPSC-derived products in combination with gene-editing technology among a representative sample of the general public in the Netherlands.
- Organize meetings with the User Committee and other stakeholders (fluency in Dutch – spoken and in writing - is necessary).
- Organize dissemination and outreach activities with stakeholders and interested parties.
The research team
This project is a collaboration between the department of Donor Studies at Sanquin Research and the department of Cell Biology at Erasmus MC. The PhD candidate will be enrolled in the Graduate School of Social Sciencesof Vrije Universiteit Amsterdam with which the department of Donor Studies has a longstanding collaboration. The department of Donor Studies is an internationally recognized center for high-quality blood donor research. Staff at the department consists of about 15 researchers, including 5 PhD students. The Erasmus MC Department of Cell Biology has ~100 researchers, including ~25 PhD students.
Stakeholders (among others )
OSCAR Nederland: https://www.oscarnederland.nl/; https://www.oscarnederland.nl/website-expertise-netwerk-sikkelcelziekte-...
Similar Positions
-
Ph D Scholarship In Applied Stem Cell Cultivation – Dtu Bioengineering, Technical University of Denmark, Denmark, 1 day ago
Skip to main content. Profile Sign Out View More Jobs PhD scholarship in Applied Stem Cell Cultivation – DTU Bioengineering Kgs. Lyngby, Denmark Trending Job Description This is a perfect position...
-
Ph D Student Position In Blood Cancer Research , University of Basel, Switzerland, 20 days ago
The Department of Biomedicine (DBM) is a joint effort between the University of Basel and the University Hospitals Basel. It unites basic and clinical scientists to advance our understanding of he...
-
Ph D Student In Vascular Cell Biology/Immunology, Leiden University, Netherlands, 4 days ago
Apply now The Faculty of Science and the Institute for Biology Leiden are looking for an: PhD student in vascular cell biology/immunology Key responsibilities The PhD student will work in close co...
-
Multiple Ph D Positions On "Single Cell Proteome Profiling" , ETH Zurich, Switzerland, about 6 hours ago
100%, Zurich, fixed-term The laboratory of Single-Molecule and Single-Cell Biophysics (BMC) is a research group in the Department of Information Technology and Electrical Engineering (D-ITET) at E...
-
Ph D Position In Germline Stem Cell Development And Fertility (Pa2024/1090) , University of Lund, Sweden, about 8 hours ago
Description of the business Our research focuses on the role of extracellular singling in cell fate decisions during development and disease. The group, led by Dr. Sandeep Gopal, is located at the...
-
Ph D Student In Vascular Cell Biology/Immunology, AcademicTransfer, Netherlands, 23 days ago
PhD student in vascular cell biology/immunology PhD student in vascular cell biology/immunology Published Deadline Location today 21 Apr Leiden The Faculty of Science and the Institute for Biology...