PhD in Peptide Chemistry

Updated: 3 months ago
Job Type: Temporary
Deadline: 01 Apr 2020

Are you a highly driven and an extremely curious person?
Do you have an MSc degree in Organic Chemistry?
Then we are looking for you!

We are looking for a PhD student (AIO) in synthetic peptide chemistry. We aim to identify and synthesize peptides that can enhance the regeneration of protoplasts into plantlets. This is of utmost and urgent importance in view of the increasing resource and areal demands to feed the world. By boosting regeneration with synthetic peptides, we can shorten the life-cycle of plants and increase the productivity. We aim for a twofold approach to this: First, you will prepare these synthetic peptides by means of established protocols, and use them to prepare libraries in order to perform a structure-activity relationship study. The design and screening of these peptides for any biological activity in regard to enhancing the regeneration capacity of protoplasts will be done in close collaboration with Wageningen Plant Research. Second, apart from having a unique chance to work on new methods to feed the world, you will also have the chance to develop environmentally sustainable peptide synthesis methods. We want to find methods that avoid the massive amounts of waste for each unit of peptide that is prepared by current optimized methods that have a typical atom efficiency of ca. 0.2 %, that are actually used world-wide as nothing better exists yet.

We are looking for an organic chemist who does not shy away from synthetic challenges. In this project, you combine solution-phase synthesis of building blocks with solid-phase synthesis of the peptides. You have the change to become a valuable member in a larger consortium that consists of academic and industrial partners. And by being part of ORC you can develop a plethora of skills, get familiar with our state-of-the-art equipment, including an automated peptide synthesizer, preparative HPLC-MS, UPLC-HR-MS, microwave synthesizer, and multiple high-end NMR machines.

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