PhD in Biomaterial-cell interaction mediated control over cell physiology

Eindhoven University of Technology is recruiting an ambitious PhD candidate who will study how biomaterials influence cell physiology through adhesion mediated control and apply this knowledge to improve the interaction of medical implants with the human body. The successful candidate is cell biology and equally interested in computational analysis and biomaterial engineering; she/he is passionate about molecular biology and has a desire to unravel biomolecular mechanisms. The research performed by the candidate is an essential link between biomaterial engineering and clinical application of biomaterials in regenerative medicine, which is the focus of the cluster Regenerative Medical Engineering.

JobDescription

Within the framework of the Materials Driven Regeneration program, the candidate will work in the lab of Prof. Jan de Boer (www.jandeboerlab.com ) on the molecular mechanism by which biomaterials control the phenotype of the cells which are in contact with them. The emphasis will be on the role of integrin-mediated signaling in the phenotypic control of fibroblasts and macrophages in the control of the foreign body response. The research use selected materials from the MDR consortium and apply high content imaging, transcriptomics and experimental cell biology to acquire data and uses data mining and computational modeling to analyze it. The PhD candidate is expected to do scientific research in the field described above, write a doctoral thesis, and publish research results in scientific journals. An educational and professional development program is offered to all PhD candidates. You will also be involved in teaching courses offered by the group, as well as contribute to the supervision of bachelor and master students.