Liver metastasis is a lethal state for multiple cancer types, and, to date, no cure is available against it. To develop effective therapies, the biological processes underlying the infiltration of cancer cells in the liver to possibly establish metastases must be elucidated. However, the lack of accurate models of the liver anatomy has been a limiting factor to determine which parameters direct the fate of circulating tumour cells (CTC) in the liver. In this project, we aim at identifying which factors are essential in this process, and more specifically, how CTCs trigger a cascade of events in the liver sinusoid favouring metastases. To this end, we will build an advanced human liver sinusoid model, in the form of an organ-on-a-chip (OoC) platform, that incorporates all essential structural, cellular, and functional features of this organ.
This project is a joined endeavour of Erasmus MC and University of Twente allying complementary expertise. The project is funded by NWO. At both institutions a PhD student will be working on the various aspects of the project. At Erasmus MC, we will focus on the liver metastasis biology using high-end molecular analyses while UTwente will be focus on the engineering aspects and the development of the OoC model. The project has shared and parallel tasks that require a close partnership between the PhD students. Joint meetings will be organized on a regular basis between the two institutions.
Similar Positions
-
Ph D Student In Molecular Biosciences, Stockholm University, Sweden, 2 days ago
Ref. No. SU FV-4880-22 at the Department of Molecular Biosciences, The Wenner-Gren Institute . Closing date: 4 February 2023. Research at the Department of Molecular Biosciences, The Wenner-Gren I...
-
Europe: 11 Ph D Positions In Msca Dn Project Rbp Regu Net, University of Santiago de Compostela (USC), Spain, about 9 hours ago
Eleven PhD positions are available in the Marie Sklodowska-Curie Doctoral Network “RBP-ReguNET – Deconstructing and Rewiring RNA-RBP regulatory networks”. RBP-ReguNet has been conceived to leverag...
-
Ph D Fellowship In Molecular Biophysics, University of Copenhagen, Denmark, about 16 hours ago
We invite applications for two PhD student positions. One position is with research focus on the exploration of biomembrane shape using computer simulations. The project is part of the research pr...
-
Ph D Position – Ai Powered Prediction And Control Of Ultrasound Mediated Cancer Therapy., University of Twente, Netherlands, 2 days ago
Vacancies PhD position – AI-powered prediction and control of ultrasound-mediated cancer therapy. Key takeaways Hours40 hr. Salary indication€ 2,541 - € 3,247 Deadline10 Feb 2023 This position is ...
-
Ph D Position – Ai Powered Prediction And Control Of Ultrasound Mediated Cancer Therapy., University of Twente (UT), Netherlands, 15 days ago
PhD position – AI-powered prediction and control of ultrasound-mediated cancer therapy. PhD position – AI-powered prediction and control of ultrasound-mediated cancer therapy. Published Deadline L...
-
Ph D Position Super Resolution Visualisation And Control Of Cellular Dynamics, Delft University of Technology, Netherlands, 9 days ago
Would you like to contribute to groundbreaking research on establishing microscopy-guided automated real-time control of biological processes, as a PhD candidate? Then this might be the vacancy fo...