Liver metastasis is a lethal state for multiple cancer types, and, to date, no cure is available against it. To develop effective therapies, the biological processes underlying the infiltration of cancer cells in the liver to possibly establish metastases must be elucidated. However, the lack of accurate models of the liver anatomy has been a limiting factor to determine which parameters direct the fate of circulating tumour cells (CTC) in the liver. In this project, we aim at identifying which factors are essential in this process, and more specifically, how CTCs trigger a cascade of events in the liver sinusoid favouring metastases. To this end, we will build an advanced human liver sinusoid model, in the form of an organ-on-a-chip (OoC) platform, that incorporates all essential structural, cellular, and functional features of this organ.
This project is a joined endeavour of Erasmus MC and University of Twente allying complementary expertise. The project is funded by NWO. At both institutions a PhD student will be working on the various aspects of the project. At Erasmus MC, we will focus on the liver metastasis biology using high-end molecular analyses while UTwente will be focus on the engineering aspects and the development of the OoC model. The project has shared and parallel tasks that require a close partnership between the PhD students. Joint meetings will be organized on a regular basis between the two institutions.
Similar Positions
-
Ph D Fellow Affiliated With The Project "Imaging Ageing Endothelium At The Nanoscale" , UiT The Arctic University of Norway, Norway, 1 day ago
Lars Åke Andersen 21st April 2024 Languages English English English Faculty of Health Sciences PhD Fellow affiliated with the project "Imaging Ageing Endothelium at the Nanoscale" Apply for this j...
-
Ph D Candidate In Membrane Dynamics And Cancer Cell Invasion , University of Oslo, Norway, 1 day ago
25th April 2024 Languages English English English PhD Candidate in membrane dynamics and cancer cell invasion Apply for this job See advertisement Job description A 3-year position in a Research F...
-
Ph D Positions In Molecular Immunology (2 X 1.0 Fte), University of Groningen, Netherlands, about 6 hours ago
Von Willebrand Factor (VWF) plays a pivotal role in blood coagulation, with its secretion from Weibel-Palade bodies (WPBs) being essential for responding to vascular trauma. Dysfunctional WPB biog...
-
Ph D Candidate In Membrane Dynamics And Cancer Cell Invasion, University of Oslo, Norway, 1 day ago
powered by: Cookie Information Nettsiden bruker cookies Vi ønsker at du skal være trygg når du bruker dette nettstedet. Vi benytter cookies for å sikre at du får en best mulig brukeropplevelse og ...
-
Ph D Positions In Molecular Immunology (2 X 1.0 Fte), University of Groningen, Netherlands, about 8 hours ago
PhD positions in Molecular Immunology (2 x 1.0 FTE) (V24.0200) « Back to the overview Job description Von Willebrand Factor (VWF) plays a pivotal role in blood coagulation, with its secretion from...
-
Ph D Position In Large Language Models For Knowledge Harvesting, Sharing, And Management, AcademicTransfer, Netherlands, 15 days ago
PhD position in Large Language Models for Knowledge Harvesting, Sharing, and Management PhD position in Large Language Models for Knowledge Harvesting, Sharing, and Management Published Deadline L...