CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD) is a prevalent inflammatory disease characterized by irreversible airflow obstruction as well as skeletal muscle wasting. The disease has high morbidity and mortality, and with more than 300 million deaths yearly, it is the 3rd leading cause of death worldwide. Disturbed damage and repair responses have been implicated in both lung and muscle pathology in COPD, resulting in airway disease, alveolar tissue destruction (emphysema) and skeletal muscle weakness. The tissue damage in COPD is irreversible and there is an urgent need to understand and target the mechanisms leading to impaired tissue regeneration in COPD. Convincing evidence implicates a role for mitochondrial impairment in lung and muscle pathology in COPD. Funded by a ZonMW-Open consortium grant, we will address this in our project MITOREG.
In the work packages of this sub-project of MITOREG, advanced cell culture models of muscle regeneration will be deployed to investigate the contribution of mitochondrial dysfunction to impaired muscle recovery in COPD. Moreover, the role of mitochondrial dynamics in muscle-lung cross-talk will be interrogated using organ on chip approaches in parallel with genetically modified mice in a model COPD, and key-findings will be verified in patient material. Finally, in the experimental models, the potential of interventions aimed at restoring mitochondrial health to improve muscle and lung tissue regeneration will be assessed.
Similar Positions
-
Ph D Position In Robotic System Integration For Musculoskeletal Robotic Hands , ETH Zurich, Switzerland, about 6 hours ago
100%, Zurich, fixed-term Project background The future of robotic manipulation lies in the development of systems that closely mimic the complex structures and capabilities of the human hand. Trad...
-
Ph D Student In Medical Science , Umeå University, Sweden, about 18 hours ago
The Department of Diagnostics and Intervention announces a doctoral position in medical science with a focus on the development of new techniques for rehabilitation and functional impairments of i...
-
Ph D Position In Experimental Infection Immunology , Karolinska Institutet, Sweden, 6 days ago
To be a doctoral student means to devote oneself to a research project under supervision of experienced researchers and following an individual study plan. For a doctoral degree, the equivalent of...
-
Ph D Student Human Milk Extracellular Vesicles For Preterm Brain Development, AcademicTransfer, Netherlands, 20 days ago
PhD student - Human milk extracellular vesicles for preterm brain development PhD student - Human milk extracellular vesicles for preterm brain development Published Deadline Location today 25 Apr...
-
Ph D Student In Vascular Cell Biology/Immunology, Leiden University, Netherlands, 4 days ago
Apply now The Faculty of Science and the Institute for Biology Leiden are looking for an: PhD student in vascular cell biology/immunology Key responsibilities The PhD student will work in close co...
-
Ph D Student Position In Blood Cancer Research , University of Basel, Switzerland, 20 days ago
The Department of Biomedicine (DBM) is a joint effort between the University of Basel and the University Hospitals Basel. It unites basic and clinical scientists to advance our understanding of he...