Tuberculosis (TB) is an infectious disease caused by the bacillus Mycobacterium Tuberculosis. Even though TB is curable, about one and a half million people succumb to it every year. Current treatments are long and with side effects: the need for new antibiotics and vaccines is obvious.
We aim to understand how gene products or proteins work within their cellular environment in health and disease. Our institute houses a state of the art cryo-Light Microscopy/Electron Microscopy correlative workflow from cellular localization, milling with focused ion beam (FIB-SEM), down to cryo-electron tomography, subvolume averaging and image processing to study how these nano-machines work under native conditions.
We seek a talented PhD candidate to join our interdisciplinary team. Our biology research focuses on unraveling, controlling and tempering the pathogenicity of Mycobacterium tuberculosis at a molecular level. The applicant will apply biochemistry to purify and characterize molecular players in isolation. The structural characterization will be mainly done by single particle analysis.
PhD Job Title: Structural insight in Mycobacterium Tuberculosis pathogenicity.
PhD advisers: Peter J. Peters and Raimond Ravelli
Organisation Unit: Nanoscopy division of the Maastricht Multimodal Molecular Imaging institute (M4I).
Recent publications of PhD students from our Lab:
Priming mycobacterial ESX-secreted protein B to form a channel-like structure.
Gijsbers A, Vinciauskaite V, Siroy A, Gao Y, Tria G, Mathew A, Sánchez-Puig N, López-Iglesias C, Peters PJ, Ravelli RBG. - Curr Res Struct Biol. 2021
Structure of the Yersinia injectisome in intracellular host cell phagosomes revealed by cryo FIB electron tomography.
Berger C, Ravelli RBG, López-Iglesias C, Kudryashev M, Diepold A, Peters PJ. - J Struct Biol. 2021 Mar;213(1):107701.
Endocytosed nanogold fiducials for improved in-situ cryo-electron tomography tilt-series alignment.
Berger C, Ravelli RBG, López-Iglesias C, Peters PJ. - J Struct Biol. 2021 Mar;213(1):107698.
Single-particle cryo-EM: alternative schemes to improve dose efficiency.
Zhang Y, Lu PH, Rotunno E, Troiani F, van Schayck JP, Tavabi AH, Dunin-Borkowski RE, Grillo V, Peters PJ, Ravelli RBG. - J Synchrotron Radiat. 2021 Sep 1;28(Pt 5):1343-1356.
Mycobacterium tuberculosis ferritin: a suitable workhorse protein for cryo-EM development.
Gijsbers A, Zhang Y, Gao Y, Peters PJ, Ravelli RBG. - Acta Crystallogr D Struct Biol. 2021
Understanding the invisible hands of sample preparation for cryo-EM.
Weissenberger G, Henderikx RJM, Peters PJ. - Nat Methods. 2021 May;18(5):463-471
Sub-pixel electron detection using a convolutional neural network.
van Schayck JP, van Genderen E, Maddox E, Roussel L, Boulanger H, Fröjdh E, Abrahams JP, Peters PJ, Ravelli RBG. - Ultramicroscopy. 2020 Nov;218:113091
Could Egg White Lysozyme be Solved by Single Particle Cryo-EM?
Zhang Y, Tammaro R, Peters PJ, Ravelli RBG. - J Chem Inf Model. 2020 May 26;60(5):2605-2613.
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