PhD Candidate in Cancer Systems Biology: Understanding Metabolic Reprogramming in Triple-negative...

Updated: 3 months ago
Job Type: Temporary
Deadline: 24 Oct 2022

Metabolic reprogramming allows cancer cells to rapidly consume nutrients and produce biomass. Targeting this altered metabolism can be a very effective treatment strategy, but development in this area has been limited. Would you like to start your academic career by tackling these challenges? Then join us as a PhD candidate and help broaden our ability to design effective cancer therapeutics.

You will work on a project funded by the Dutch Cancer Society, focused on identifying metabolic vulnerabilities in triple-negative breast cancer. Your research will include both experimental ('wet-lab') and theoretical ('dry-lab') components. You will have the opportunity to design and conduct a range of experiments in 2D and 3D tissue culture using breast cancer cell lines and patient-derived organoids; develop data-driven models of metabolism and other cellular processes; computationally simulate cancer cell behaviour to predict effective therapeutic targets; and validate your predictions through experimentation. You will gain a strong foundation in the molecular and systems biology of triple-negative breast cancer, state-of-the-art omics technologies, and computational approaches to integrate multi-omics 'big data'.

You will be working in an interactive and multidisciplinary environment in the Molecular Developmental Biology group at RIMLS, under the supervision of Dr Rosemary Yu. As part of your PhD training, you will assist in one or two courses a year and supervise BSc and MSc students within the context of your project.
Your teaching load may be up to 10% of your working time.

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