PhD candidate 'Germline cancer predisposition in adolescents and young adults'

Updated: 5 months ago
Deadline: 23 May 2023

4 May 2023
Job Information

Radboud University Medical Center (Radboudumc)
Research Field

Medical sciences
Researcher Profile

First Stage Researcher (R1)

Application Deadline

23 May 2023 - 22:00 (UTC)
Type of Contract

Job Status

Not Applicable
Hours Per Week

Is the job funded through the EU Research Framework Programme?

Not funded by an EU programme
Is the Job related to staff position within a Research Infrastructure?


Offer Description

Have you ever wondered why some people develop cancer and others do not? A considerable proportion of cancers that develop at Adolescent or Young Adult age (AYA; 18-39 years) are related to a hereditary germline genetic predisposing variant: a genetic tumour risk syndrome (GENTURIS). However, germline genetic testing is nowadays considered in only a minority of AYAs with cancer, as data on clinical validity and utility of these tests are lacking for many tumour types. Will you work with the team to ensure that the lacking information is completed?

During this 4-year PhD project you will identify the proportion of AYAs who developed a carcinoma that is related to a known germline pathogenic variant that predisposes to cancer. You will create knowledge on the development of cancers at AYA age by analysing both germline variation, somatic alterations and mutational signatures. Furthermore, you will formulate an advice for appropriate germline genetic testing of AYAs with cancer.

Tasks and responsibilities

  • Select and collect normal and tumour samples from the Public Pathology Database (PALGA).
  • Whole-exome sequencing analyses of germline DNA.
  • Analyse tumours for their mutational profiles using next-generation sequencing based molecular techniques.
  • Bioinformatics and statistical analyses.
  • Write scientific manuscripts.
  • Design and perform scientific research in the area of cancer genomics.
  • Present findings at local and (inter)national scientific meetings.
  • Work in a multidisciplinary team with other PhD candidates, scientists and medical doctors to discuss, plan and perform research.
  • Finish the project with a scientific dissertation.

Specific Requirements

As a PhD candidate in this project, you must have completed a Masters degree in Molecular Biology/Genetics, Medical Biology or equivalent. We are looking for an enthusiastic candidate with a strong interest in oncology and genetics. Experience with next-generation sequencing technologies, bioinformatics and statistical analysis is an advantage. You also have good social and strong communication skills (fluent in English), a critical scientific attitude and the ability to work both independently as well as in an interdisciplinary team.

Additional Information

The salary depends on education. Scale 10 will be offered to MSc medical graduates; those holding degrees in other disciplines will be offered scale 10A.

Working at Radboud university medical center means that you are ahead of the curve and working together on the healthcare of the future. And there is more. Our secondary terms of employment are impressive. These are fully tailored to you thanks to our Employment Conditions Selection Model. At Radboud university medical center, you will be given trust, and you will take the responsibility to handle everything together.

  • A gross monthly salary between € 2.789 and € 3.536 (scale 10A) or between € 3.230 and € 5.088 (scale 10) based on full-time employment.
  • From 1 November 2023 the wages will increase by 4%.
  • An annual vacation allowance of 8% and an end-of-year bonus of 8.3%.
  • If you work irregular hours, you will receive an allowance.
  • As a full-time employee (36 hours per week), you are entitled to approximately 168 vacation hours (over 23 days) per year.
  • Radboud university medical center pays 70% of the pension premium. You pay the rest of the premium with your gross salary.
  • You get a discount on health insurance as well: you can take advantage of two group health insurance plans. UMC Zorgverzekering and CZ collectief.
  • We provide annual courses, both professional and personal.

In addition to our terms of employment , we also offer employees various other attractive facilities, such as childcare and sports facilities. Want to learn more? Take a look at the CAO UMC .

Selection process

Any questions? Please contact Dr. Richarda M. de Voer , senior researcher. Use the Apply button to submit your application.

Additional comments

Any questions? Please contact Dr. Richarda M. de Voer , senior researcher. Use the Apply button to submit your application.

Website for additional job details

Work Location(s)
Number of offers available
Postal Code
6525 GA
Geert Grooteplein-Zuid 10

Where to apply



Geert Grooteplein-Zuid 10
Postal Code

6525 GA

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