The cause of thrombosis lies within the three pillars based on Virchows’ Triad: vessel, flow, and blood. Traditionally these three pillars are approached separately by research. This project will utilize world leading expertise of these three pillars to combine them into development of a novel stem cell model, Virchows’ Organoid. The project will involve pluripotent stem cell culture, vascular cell differentiation (endothelial and vascular smooth muscle cell), CRISPRCas9 gene editing and flow-mechanics to build a model to study the three pillars of Virchows’ Triad. This interdisciplinary approach will allow novel understanding of coagulation and thrombosis by combining vessel wall (imaging and RNA-sequencing), flow dynamics (platelet flow) and changes to blood protein biochemistry (ELISA) in a single model, termed Virchows’ Organoid.
The successful applicant will be placed in the Department of Biochemistry, CARIM in our newly established pluripotent stem cell facility under guidance of Prof. Leon Schurgers (vessels). The research group is multidisciplinary and collaborates closely with the HeartVascular-Center (HVC) of MUMC+, as well as the Department of Experimental Medicine and Systems Biology (UniKlinikum Aachen) and University California, Irvine (UCI).
Internally within the department of Biochemistry the successful applicant will receive cosupervision from Dr Judith Cosemans (flow) and Dr Henri Spronk (blood biochemistry). Furthermore, the successful applicant will benefit from the friendly and inclusive culture of the laboratory with a highly motivating working environment in the city of Maastricht. There is possibility of international placement to collaborator labs in California (Prof Hughes) or Germany (Prof Kramann) depending on what is suitable for the candidate’s development and interests.
Ph D Candidate (M/W/D), E13/65 % , Technical University of Munich, Germany, about 20 hours ago
11.10.2021, Wissenschaftliches Personal We are looking for a PhD candidate (m/w/d) who wants to employ cutting-edge single-cell fate mapping to decipher how CD4 T cells adapt to chronic infection ...
2 Ph D Positions ‘Development Of A Culture System For Human Spermatogenesis’, Academic Medical Center (AMC), Netherlands, 24 days ago
Two PhD candidates will develop an in vitro culture system for human spermatogenesis. Successful in vitro spermatogenesis can form the basis for novel methods to treat patients with impaired sperm...
Postdoctoral Scholarship In Vivo Drug Discovery For Beta Cell Regeneration, Karolinska Institute, Sweden, about 15 hours ago
Do you want to contribute to top quality medical research? The research group The Department of Cell and Molecular Biology (CMB) is a department with a strong focus on basic science. CMB conducts ...
Research Assistant (Ph D Student), University of Bucharest, Romania, 7 days ago
-PhD student in Biology; - Bachelor in Biomedical field; - at least 2 years of research experience in the Biomedical field; - experience in: establishment of normal and/ or tumor cell cultures, ma...
Postdoctoral Position In Cell Biology, Hospital Universitario de La Princesa, Spain, 17 days ago
The Inflammatory Bowel Disease Research Group led by Dr. Javier P. Gisbert and María Chaparro at Hospital Universitario de La Princesa (Madrid) is currently looking for postdoctoral candidates wil...
Postdoctoral Position (Biologist) To Study Tumor States During Cancer Progression, Metastasis And..., Université libre de Bruxelles, Belgium, 16 days ago
Our laboratory is studying the mechanisms regulating stem cells and tumor heterogeneity (See recent publications: Sánchez-Danés Nature 2016, Latil, Cell Stem Cell 2017, Sánchez-Danés Nature 2018, ...